|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|1358562||981349||2016||4 صفحه PDF||سفارش دهید||دانلود کنید|
The objective of this study was to develop a positron emission tomography (PET) probe with hypoxia targeting specificity and a relatively long half-life. The synthesis, 64Cu-labeling in vitro and in vivo study of the novel 2-nitroimidazole complex 64Cu-BMS2P2 is presented in this study. The hypoxia targeting capacity of 64Cu-BMS2P2 in vitro was evaluated and compared with the 64Cu-BMS181321, and confirmed by PET imaging in vivo and immunohistochemistry for carbonic anhydrase 9 (CA9) in a tumor mouse model. These results suggest that 64Cu-BMS2P2 is a promising candidate for PET hypoxia imaging and worthy of further investigations in dynamic hypoxia imaging.
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Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 5, 1 March 2016, Pages 1397–1400