کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1358576 981349 2016 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
Evaluation of synthetic coumarins for antiausterity cytotoxicity against pancreatic cancers
ترجمه فارسی عنوان
ارزیابی کومارین های مصنوعی برای سمیت سلولی ضدریاضت در برابر سرطان های پانکراس
کلمات کلیدی
عوامل Antiausterity؛ سرطان پانکراس؛ کومارین ها؛ آپوپتوز؛ گرسنگی مقاومت
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A series of functionalized coumarins were synthesized and evaluated for their capacity to inhibit the resistance to starvation of pancreatic cancer cells. This form of cytotoxicity, termed ‘antiausterity’ activity, was evaluated using a preferential cytotoxicity assay that compared cell survival in nutrient poor and nutrient rich conditions. Six of the seventeen compounds showed weak antiausterity activity against PANC-1. Compound 34 was active against PANC-1, MIA PaCa-2, and Capan-1 cancer cell lines. All of the compounds tested were simplified structural analogs of previously reported natural product leads. Six of the compounds, including 34, contain functionalized triazoles as novel potential bioisosteres of the side chain of the natural product angelmarin. Overall, the analogs were found to have low antiausterity activity relative to the corresponding natural products.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 5, 1 March 2016, Pages 1471–1474
نویسندگان
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