Recent progress in biocatalysis using supercritical carbon dioxide

The latest advances in biocatalysis using supercritical carbon dioxide (scCO2) are reviewed. Stability and stabilization methodologies of enzymes in scCO2 as well as reactions for organic synthesis are described. Especially, varieties of examples for lipase-catalyzed synthesis of chiral compounds using scCO2 are given. Furthermore, asymmetric reduction by alcohol dehydrogenase in scCO2 and carboxylation by decarboxylase in scCO2 are also introduced.