کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5764089 | 1625914 | 2017 | 40 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heat indicators of oxidative stress, inflammation and metal transport show dependence of cadmium pollution history in the liver of female zebrafish
ترجمه فارسی عنوان
شاخص های گرمای استرس اکسیداتیو، التهاب و حمل و نقل فلز، وابستگی تاریخچه آلودگی کادمیوم را در کبد ماهی گیر
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کلمات کلیدی
Nrf2HSF1IL-1βATP7Bhsp70copper/zinc-superoxide dismutaseZIP8iNOSATP7ALPOMTF-1CATCTR1Zinc transporter 1IL-6HSF2NF-κBinterleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βOxidative stress - تنش اکسیداتیوtumor necrosis factor-α - تومور نکروز عامل αMetal transport - حمل و نقل فلزیCopper transporter - حمل و نقل مسHigh temperature - درجه حرارت بالاinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییNF-E2-related factor 2 - عامل NF-E2 2heat shock factor 1 - عامل شوک گرما 1Nuclear transcription factor κB - فاکتور رونویسی هسته ای κBTNF-α - فاکتور نکروز توموری آلفاFish - ماهیMetallothioneins - متالوتیژیونCu/Zn-SOD - مس / روی-SODImmunity - مصونیتLipid peroxidation - پراکسیداسیون لیپیدheat shock protein 70 - پروتئین شوک حرارت 70Catalase - کاتالاز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم آبزیان
چکیده انگلیسی
Environmental stressors such as high temperature and metal exposure may occur sequentially, simultaneously, previously in aquatic ecosystems. However, information about whether responses to high temperature depend on Cd exposure history is still unknown in fish. Zebrafish were exposed to 0 (group 1), 2.5 (group 2) and 5 μg/L (group 3) cadmium (Cd) for 10 weeks, and then each group was subjected to Cd-free water maintained at 26 °C and 32 °C for 7 days respectively. 26 indicators were used to compare differences between 26 °C and 32 °C in the liver of female zebrafish, including 5 biochemical indicators (activity of Cu/Zn-SOD, CAT and iNOS; LPO; MT protein), 8 molecular indicators of oxidative stress (mRNA levels of Nrf2, Cu/Zn-SOD, CAT, HSF1, HSF2, HSP70, MTF-1 and MT), 5 molecular indicators of inflammation (mRNA levels of IL-6, IL-1β, TNF-α, iNOS and NF-κB), 8 molecular indicators of metal transport (mRNA levels of, ZnT1, ZnT5, ZIP8, ZIP10, ATP7A, ATP7 B and CTR1). All biochemical indicators were unchanged in group 1 and changed in group 2 and 3. Contrarily, differences were observed in almost all of molecular indicators of inflammation and metal transport in group 1, about half in group 2, and few in group 3. We also found that all molecular indicators of oxidative stress in group 2 and fewer in group 1 and 3 were significantly affected by heat. Our data indicated that heat indicators of oxidative stress, inflammation and metal transport showed dependence of previous cadmium exposure in the liver of zebrafish, emphasizing metal pollution history should be carefully considered when evaluating heat stress in fish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Aquatic Toxicology - Volume 191, October 2017, Pages 1-9
Journal: Aquatic Toxicology - Volume 191, October 2017, Pages 1-9
نویسندگان
Qing-Ling Zhu, Sai-Nan Guo, Shuang-Shuang Yuan, Zhen-Ming Lv, Jia-Lang Zheng, Hu Xia,