کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844274 | 1561030 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice
ترجمه فارسی عنوان
شواهد اثرات محافظتی اسید لیپوئیک و دوزونلافاکسین بر استرس اکسیداتیو در افسردگی مدل در موش
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کلمات کلیدی
ALAMDASNRIDesvenlafaxineMDDGSHCATDVSPFCPMd - PMDROS - ROSMajor depressive disorder - اختلال افسردگی عمدهStriatum - استریاتومalpha-lipoic acid - اسید آلفا لیپوئیکDepression - افسردگیPsychotic major depression - افسردگی شدید روانیSerotonin and noradrenaline reuptake inhibitor - بازدارنده بازگشت سراتونین و نورآدرنالینOxidative stress - تنش اکسیداتیوSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازprefrontal cortex - قشر prefrontalLipoic acid - لیپوئیک اسیدmalondialdehyde - مالون دی آلدهیدselective serotonin reuptake inhibitors - مهار کننده های بازجذب سروتونین انتخابیSSRI - مهارکنندههای بازجذب سروتونینHippocampus - هیپوکامپ Lipid peroxidation - پراکسیداسیون لیپیدCatalase - کاتالازreduced glutathione - کاهش گلوتاتیونCORT - کورتCorticosterone - کورتیکوسترونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Oxidative stress is implicated in the neurobiology of depression. Here we investigated oxidative alterations in brain areas of animals submitted to the model of depression induced by corticosterone (CORT) and the effects of the antioxidant compound alpha-lipoic acid (ALA) alone or associated with the antidepressant desvenlafaxine (DVS) in these alterations. Female mice received vehicle or CORT (20Â mg/kg) during 14Â days. From the 15th to 21st days different animals received further administrations of: vehicle, DVS (10 or 20Â mg/kg), ALA (100 or 200Â mg/kg), or the combinations of DVS10Â +Â ALA100, DVS20Â +Â ALA100, DVS10Â +Â ALA200, or DVS20Â +Â ALA200. Twenty-four hours after the last drug administration prefrontal cortex (PFC), hippocampus (HC) and striatum (ST) were dissected for the determination of the activity of superoxide dismutase (SOD), reduced glutathione (GSH) and lipid peroxidation (LP) levels. CORT significantly increased SOD activity in the PFC and HC, decreased GSH levels in the HC and increased LP in all brain areas studied when compared to saline-treated animals. Decrements of SOD activity were observed in all groups and brain areas studied when compared to controls and CORT. The hippocampal decrease in GSH was reversed by ALA100, DVS10Â +Â ALA100, DVS20Â +Â ALA100 and DVS20Â +Â ALA200. The same DVSÂ +Â ALA combination groups presented increased levels of GSH in the PFC and ST. The greater GSH levels were observed in the PFC, HC and ST of DVS20Â +Â ALA200 mice. LP was reversed in the groups ALA200 (PFC), DVS10Â +Â ALA100, DVS20Â +Â ALA100 (PFC, HC and ST), and DVS20Â +Â ALA200 (PFC, HC). Our findings contribute to the previous preclinical evidences implicating ALA as a promising agent for augmentation therapy in depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 64, 4 January 2016, Pages 142-148
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 64, 4 January 2016, Pages 142-148
نویسندگان
Márcia Calheiros Chaves Silva, Caren Nádia Soares de Sousa, PatrÃcia Xavier Lima Gomes, Gersilene Valente de Oliveira, Fernanda Yvelize Ramos Araújo, Naiara Coelho Ximenes, Jéssica Calheiros da Silva, Germana Silva Vasconcelos,