Extraction of Dracocephalum kotschyi Boiss using supercritical carbon dioxide: Experimental and optimization

- Essential oil of Dracocephalum kotschyi was extracted by supercritical CO2 for the first time.
- Response surface methodology (RSM) was utilized for prediction and optimization.
- Differential evolution (DE) methodology was also used to optimize the process parameters.
- Prediction of the optimal operating conditions was verified by performing the experiments.