کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536943 | 1560923 | 2018 | 49 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of osteoprotegerin in the crosstalk between vessels and bone: Its potential utility as a marker of cardiometabolic diseases
ترجمه فارسی عنوان
نقش استئوپروتگرین در تداخل بین عروق و استخوان: ابزار بالقوه آن به عنوان نشانگر بیماری های قلبی و متابولیک
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کلمات کلیدی
GDF-15EVSFGF-23ADMAECFCGAGGLACRDCysEPCECDALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییamino acid - آمینو اسیدgamma-carboxyglutamic acid - اسید گاما کربوکسیگلوتامیکcoronary artery disease - بیماری عروق کرونرcardiovascular disease - بیماری قلب و عروقیchronic kidney disease - بیماری مزمن کلیویExtracellular vesicles - حامل های خارج سلولیextracellular domain - دامنه خارج سلولیcysteine rich domain - دامنه غنی از سیستینasymmetric dimethylarginine - دی متیل آرژینین نامتقارنCVD - رسوب دهی شیمیایی بخار Endothelial colony-forming cell - سلول تشکیل دهنده کلنی اندوتلیالEndothelial cell - سلول های اندوتلیالEndothelial progenitor cell - سلول پیش ساز اندوتلیالCysteine - سیستئینbody mass index - شاخص توده بدنBMI - شاخص توده بدنیCAD - طراحی به کمک رایانه یا کَدgrowth differentiation factor-15 - عامل تمایز رشد -15Fibroblast growth factor-23 - فیبروبلاست رشد فاکتور 23Atrial fibrillation - فیبریلاسیون دهلیزیBMP - مدیریت فرایند کسب و کارCKD - نارسایی مزمن کلیهBone morphogenetic protein - پروتئین مورفوژنیک استخوانGlycosaminoglycan - گلیکوزآمینوگلیکانEstrogen receptor - گیرنده استروژنDeath receptors - گیرنده های مرگ
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
Among the numerous molecules that are being studied for their potential utility as biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of tumor necrosis factor (TNF) receptors. Members of this family include osteoprotegerin (OPG) and its ligands, which are receptor activators of nuclear factor κB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). These signals may be expressed and regulated, and their functions could be involved in several physiological and pathological processes. The relationship between bone regulatory proteins and vascular biology has attracted attention, and it has been suggested that OPG may mediate vascular calcification and cardiometabolic diseases. OPG is steadily released from vascular endothelial cells in response to inflammatory stimuli, suggesting that it plays a modulatory role in vascular injury, inflammation, and atherosclerosis. Vascular calcification, a hallmark of atherosclerosis, is similar to bone remodeling. It is an actively regulated mechanism that includes both inductive and inhibitory processes. There is a temporal link between the development of osteoporosis and vascular calcification, which is particularly marked in post-menopausal women and the elderly. The precise nature of the link between bone metabolism, vascular calcification and cardiovascular disease is largely unknown but increasing evidence suggests that the triad of RANK/RANKL/OPG may be important in the initiation of various diseases. An increased release of OPG is associated with increased cardiovascular risk and it is suggested that increased OPG levels resulting from vascular damage correspond to a protective mechanism. Circulating OPG levels could be used as independent biomarkers of cardiovascular disease in patients with acute or chronic cardiometabolic disease and thus an improved prognosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 182, February 2018, Pages 115-132
Journal: Pharmacology & Therapeutics - Volume 182, February 2018, Pages 115-132
نویسندگان
Luc Rochette, Alexandre Meloux, Eve Rigal, Marianne Zeller, Yves Cottin, Catherine Vergely,