Potential new antitumor agents from an innovative combination of camphorato, a ramification of traditional Chinese medicine, with a platinum moiety Fulltext Access 6 Pages 2005
Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists Fulltext Access 6 Pages 2005
Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists Fulltext Access 6 Pages 2005
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase Fulltext Access 6 Pages 2005
Exploring the connection unit in the HDAC inhibitor pharmacophore model: Novel uracil-based hydroxamates Fulltext Access 6 Pages 2005
Radical scavenging activity of protein from tentacles of jellyfish Rhopilema esculentum Fulltext Access 6 Pages 2005
Design, synthesis and structure–activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae Fulltext Access 6 Pages 2005
Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity Fulltext Access 6 Pages 2005
A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice Fulltext Access 6 Pages 2005
Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid Fulltext Access 6 Pages 2005
Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents Fulltext Access 6 Pages 2005
Synthesis and antipicornavirus activity of (R)- and (S)-1-[5-(4′-chlorobiphenyl-4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one Fulltext Access 6 Pages 2005
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors Fulltext Access 6 Pages 2005
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties Fulltext Access 6 Pages 2005
Structure–activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities Fulltext Access 6 Pages 2005
QSAR analyses of conformationally restricted 1,5-diaryl pyrazoles as selective COX-2 inhibitors: application of connection table representation of ligands Fulltext Access 6 Pages 2005
Benzothiazolium compounds: novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFNγ Fulltext Access 6 Pages 2005
Bicyclic nucleoside inhibitors of Varicella–Zoster virus: The effect of branching in the p-alkylphenyl side chain Fulltext Access 6 Pages 2005
A physicogenetic method to assign ligand-binding relationships between 7TM receptors Fulltext Access 6 Pages 2005
1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists Fulltext Access 6 Pages 2005
Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists Fulltext Access 6 Pages 2005
A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists Fulltext Access 6 Pages 2005
13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit Fulltext Access 6 Pages 2005
Cancer preventive agents. Part 1: Chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds Fulltext Access 6 Pages 2005
Antioxidant activity of differently regioselective chitosan sulfates in vitro Fulltext Access 6 Pages 2005
On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I-DNA covalent binary complex Fulltext Access 6 Pages 2005
Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity Fulltext Access 6 Pages 2005
Technetium-99m labelled integrated tropane-BAT as a potential dopamine transporter tracer Fulltext Access 6 Pages 2005
A theoretical study on the structure-activity relationships of metabolites of folates as antioxidants and its implications for rational design of antioxidants Fulltext Access 6 Pages 2005
Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c]phenanthridine-type alkaloid, and its structure-activity relationship, studied by X-ray crystal structure analysis and molecular docking study Fulltext Access 6 Pages 2005
Topological models for the prediction of anti-HIV activity of dihydro (alkylthio) (naphthylmethyl) oxopyrimidines Fulltext Access 6 Pages 2005
Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds Fulltext Access 6 Pages 2005
Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids Fulltext Access 6 Pages 2005
Synthesis and antiproliferative activity of [1,2,3,5]tetrazino[5,4-a]indoles, a new class of azolo-tetrazinones Fulltext Access 6 Pages 2005
Amino substituted derivatives of 5â²-amino-5â²-deoxy-5â²-noraristeromycin Fulltext Access 6 Pages 2005
Structure identification and prophylactic antimalarial efficacy of 2-guanidinoimidazolidinedione derivatives Fulltext Access 6 Pages 2005
Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole–imidazole polyamides Fulltext Access 6 Pages 2005
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff’s bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes Fulltext Access 6 Pages 2005
Structure-based design and synthesis of pyrazinones containing novel P1 ‘side pocket’ moieties as inhibitors of TF/VIIa Fulltext Access 6 Pages 2005
Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator Fulltext Access 6 Pages 2005
In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine Fulltext Access 6 Pages 2005
Discovery and structure–activity relationships of novel sulfonamides as potent PTP1B inhibitors Fulltext Access 6 Pages 2005
Irreversibly inhibitory kinetics of 3,5-dihydroxyphenyl decanoate on mushroom (Agaricus bisporus) tyrosinase Fulltext Access 6 Pages 2005
Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino Fulltext Access 6 Pages 2005
3-N,N-Dimethylamino-3-deoxy lincomycin: A structure-based hybrid between lincomycin and the desosamine unit of erythromycin Fulltext Access 6 Pages 2005
Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic marine dinoflagellate Symbiodinium sp. Fulltext Access 6 Pages 2005
On the mechanism of isomerization of all-trans-retinol esters to 11-cis-retinol in retinal pigment epithelial cells: 11-Fluoro-all-trans-retinol as substrate/inhibitor in the visual cycle Fulltext Access 6 Pages 2005
New 1,2,3,4-tetrahydro-1-aza-anthraquinones and 2-aminoalkyl compounds from norlapachol with molluscicidal activity Fulltext Access 6 Pages 2005
3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method Fulltext Access 6 Pages 2005
Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells Fulltext Access 6 Pages 2005
Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening Fulltext Access 6 Pages 2005
QSAR studies of paeonol analogues for inhibition of platelet aggregation Fulltext Access 6 Pages 2005
Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides Fulltext Access 6 Pages 2005
Novel synthetic isoquinolino[5,4-ab]phenazines: Inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities Fulltext Access 6 Pages 2005
Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives Fulltext Access 6 Pages 2005
QSAR of the testosterone binding globulin affinity by means of correlation weighting of local invariants of the graph of atomic orbitals Fulltext Access 6 Pages 2005
2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT Inhibitors Fulltext Access 6 Pages 2005
Multifunctional action of antifungal polygodial against Saccharomyces cerevisiae: Involvement of pyrrole formation on cell surface in antifungal action Fulltext Access 6 Pages 2005
Isolation, characterization and biological evaluation of datura lactones as potential immunomodulators Fulltext Access 6 Pages 2005
Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides—a new zinc-binding function in the design of inhibitors Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies Fulltext Access 6 Pages 2005
Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole Fulltext Access 6 Pages 2005
Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase Fulltext Access 6 Pages 2005
Identification of synthetic compounds active against VRE: the role of the lipidated aminoglucose and the structure of glycopeptide binding pocket Fulltext Access 6 Pages 2005
A new class of high affinity thyromimetics containing a phenyl-naphthylene core Fulltext Access 6 Pages 2005
Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists Fulltext Access 6 Pages 2005
ERβ ligands. Part 4: Synthesis and structure–activity relationships of a series of 2-phenylquinoline derivatives Fulltext Access 6 Pages 2005
First QSAR report on FSH receptor antagonistic activity: Quantitative investigations on physico-chemical and structural features among 6-amino-4-phenyltetrahydroquinoline derivatives Fulltext Access 6 Pages 2005
1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors Fulltext Access 6 Pages 2005
Interaction of cromolyn sodium with human serum albumin: A fluorescence quenching study Fulltext Access 6 Pages 2005
Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization Fulltext Access 6 Pages 2005
Geometric diversity through permutation of backbone configuration in cyclic peptide libraries Fulltext Access 6 Pages 2005
Two classes of p38α MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes Fulltext Access 6 Pages 2005
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives Fulltext Access 6 Pages 2005
Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor Fulltext Access 6 Pages 2005
Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy Fulltext Access 6 Pages 2005
Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: New lead compounds for the development of anticancer agents Fulltext Access 6 Pages 2005
Synthesis and structure–activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors Fulltext Access 6 Pages 2005
Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with l-histidine as a platform for the design of stronger activators Fulltext Access 6 Pages 2005
Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints Fulltext Access 6 Pages 2005
Studies on interaction of an intramolecular charge transfer fluorescence probe: 4′-Dimethylamino-2,5-dihydroxychalcone with DNA Fulltext Access 6 Pages 2005