Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase Fulltext Access 6 Pages 2005
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity Fulltext Access 6 Pages 2005
Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives Fulltext Access 6 Pages 2005
N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP Fulltext Access 6 Pages 2005
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle Fulltext Access 6 Pages 2005
Synthesis and in vitro study of novel Mannich bases as antibacterial agents Fulltext Access 6 Pages 2005
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase Fulltext Access 6 Pages 2005
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties Fulltext Access 6 Pages 2005
Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase) Fulltext Access 6 Pages 2005
Combinatorial approaches towards the discovery of new tryptase inhibitors Fulltext Access 6 Pages 2005
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II Fulltext Access 6 Pages 2005
Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides Fulltext Access 6 Pages 2005
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13) Fulltext Access 6 Pages 2005
Conformational analysis of rhazinilam and three-dimensional quantitative structure-activity relationships of rhazinilam analogues Fulltext Access 6 Pages 2005
Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA) Fulltext Access 6 Pages 2005
Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists Fulltext Access 6 Pages 2005
Molecular docking of the highly hypolipidemic agent α-asarone with the catalytic portion of HMG-CoA reductase Fulltext Access 6 Pages 2005
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides Fulltext Access 6 Pages 2005
Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters Fulltext Access 6 Pages 2005
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors Fulltext Access 6 Pages 2005
Quest for the Holy Grail to cure arthritis and osteoporosis: Emphasis on bone drug delivery systems Fulltext Access 6 Pages 2005
Drug-incorporating calcium carbonate nanoparticles for a new delivery system Fulltext Access 6 Pages 2005
Synthesis of a library of benzoindolizines using poly(ethylene glycol) as soluble support Fulltext Access 6 Pages 2005
A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX Fulltext Access 6 Pages 2005
Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives Fulltext Access 6 Pages 2005
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists Fulltext Access 6 Pages 2005
Synthesis and properties of polysaccharide prodrugs of 5-aminosalicylic acid as potential colon-specific delivery systems Fulltext Access 6 Pages 2005
1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR Fulltext Access 6 Pages 2005
Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B Fulltext Access 6 Pages 2005
A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists Fulltext Access 6 Pages 2005
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates Fulltext Access 6 Pages 2005
New conformationally locked bicyclic N,O-nucleoside analogues of antiviral drugs Fulltext Access 6 Pages 2005
Identification of putative metabolites of docosahexaenoic acid as potent PPARγ agonists and antidiabetic agents Fulltext Access 6 Pages 2005
3,4-Disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity Fulltext Access 6 Pages 2005
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction Fulltext Access 6 Pages 2005
Design and synthesis of novel 9-substituted-7-aryl-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]- and [2,3-b]-1,5-oxazocin-6-ones as NK1 antagonists Fulltext Access 6 Pages 2005
Structure–affinity relationships of halogenated predicentrine and glaucine derivatives at D1 and D2 dopaminergic receptors: halogenation and D1 receptor selectivity Fulltext Access 6 Pages 2005
Structure–affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor Fulltext Access 6 Pages 2005
Position-specific incorporation of a highly photodurable and blue-laser excitable fluorescent amino acid into proteins for fluorescence sensing Fulltext Access 6 Pages 2005
Synthesis and antioxidant, anti-inflammatory and gastroprotector activities of anethole and related compounds Fulltext Access 6 Pages 2005
Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein transacetylase Fulltext Access 6 Pages 2005
Synthesis and characterization of novel 6-fluoro-4-piperidinyl-1,2-benzisoxazole amides and 6-fluoro-chroman-2-carboxamides: antimicrobial studies Fulltext Access 6 Pages 2005
Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives Fulltext Access 6 Pages 2005
1′S-1′-Acetoxychavicol acetate as a new type inhibitor of interferon-β production in lipopolysaccharide-activated mouse peritoneal macrophages Fulltext Access 6 Pages 2005
Topological models for prediction of anti-HIV activity of acylthiocarbamates Fulltext Access 6 Pages 2005
Thiourea-based non-nucleoside inhibitors of HIV reverse transcriptase as bifunctional organocatalysts in the asymmetric Strecker synthesis Fulltext Access 6 Pages 2005
Synthesis, characterisation and cytotoxicity of chloro derivatives of prenylnaphthohydroquinone Fulltext Access 6 Pages 2005
Inclusion complexes of azadirachtin with native and methylated cyclodextrins: solubilization and binding ability Fulltext Access 6 Pages 2005
Theoretical study revealing the functioning of a novel combination of catalytic motifs in histone deacetylase Fulltext Access 6 Pages 2005
Synthesis and antimycobacterial evaluation of certain fluoroquinolone derivatives Fulltext Access 6 Pages 2005
N,N′-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA Fulltext Access 6 Pages 2005
Steroid-derived phospholipid scramblases induce exposure of phosphatidylserine on the surface of red blood cells Fulltext Access 6 Pages 2005
‘Green’ methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid Fulltext Access 6 Pages 2005
Synthesis and structure-activity relationships of 2-alkylidenethiazolidine-4,5-diones as antibiotic agents Fulltext Access 6 Pages 2005
Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters Fulltext Access 6 Pages 2005
Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) microcrystalline cellulose Fulltext Access 6 Pages 2005
Determination of hypericin in human plasma by high-performance liquid chromatography after intravesical administration in patients with transitional cell carcinoma of the bladder Fulltext Access 6 Pages 2005
Compressibility of floating pellets with verapamil hydrochloride coated with dispersion Kollicoat SR 30 D Fulltext Access 6 Pages 2005
Polymethacrylates as crystallization inhibitors in monolayer transdermal patches containing ibuprofen Fulltext Access 6 Pages 2005
Topical delivery of cyclosporin A: an in vitro study using monoolein as a penetration enhancer Fulltext Access 6 Pages 2005
Topical glycerol monooleate/propylene glycol formulations enhance 5-aminolevulinic acid in vitro skin delivery and in vivo protophorphyrin IX accumulation in hairless mouse skin Fulltext Access 6 Pages 2005
Use of CP/MAS solid-state NMR for the characterization of solvate molecules within estradiol crystal forms Fulltext Access 6 Pages 2005
Synthesis of new phorbol derivatives having ethereal side chain and evaluation of their anti-HIV activity Fulltext Access 6 Pages 2005
A comparative study of the utility of two superdisintegrants in microcrystalline cellulose pellets prepared by extrusion-spheronization Fulltext Access 6 Pages 2005
Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate Fulltext Access 6 Pages 2005
Enhanced efficacy of triprolidine by transdermal application of the EVA matrix system in rabbits and rats Fulltext Access 6 Pages 2005
Chitosan and poly(methyl vinyl ether-co-maleic anhydride) microparticles as nasal sustained delivery systems Fulltext Access 6 Pages 2005
Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives Fulltext Access 6 Pages 2005
Microbial transformation of (−)-isolongifolol and butyrylcholinesterase inhibitory activity of transformed products Fulltext Access 6 Pages 2005
Studies on the cytochrome P450 catalyzed oxidation of 13C labeled 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine by 13C NMR Fulltext Access 6 Pages 2005
Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe Fulltext Access 6 Pages 2005
Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF Fulltext Access 6 Pages 2005