Original ResearchLongitudinal Use of Complementary and Alternative Medicine Among Older Adults With Radiographic Knee Osteoarthritis Fulltext Access 13 Pages 2013
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat Fulltext Access 13 Pages 2013
Systematic Review of Tumor Necrosis Factor Inhibitor Discontinuation Studies in Rheumatoid Arthritis Fulltext Access 13 Pages 2013
Descriptive Comparison of Drug Treatment-Persistent, -Nonpersistent, and Nondrug Treatment Patients With Newly Diagnosed Attention Deficit/Hyperactivity Disorder in Germany Fulltext Access 13 Pages 2013
Non-psychotropic analgesic drugs from the endocannabinoid system: “Magic bullet” or “multiple-target” strategies? Fulltext Access 13 Pages 2013
ReviewExcitotoxicity: Bridge to various triggers in neurodegenerative disorders Fulltext Access 13 Pages 2013
Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders? Fulltext Access 13 Pages 2013
Molecular and cellular pharmacologyThe effect of oxidative stress upon the intestinal epithelial uptake of butyrate Fulltext Access 13 Pages 2013
ReviewClinical management and infection control of SARS: Lessons learned Fulltext Access 13 Pages 2013
The Effect of Ticagrelor on the Metabolism of Midazolam in Healthy Volunteers Fulltext Access 13 Pages 2013
ReviewNew-generation screening assays for the detection of anti-influenza compounds targeting viral and host functions Fulltext Access 13 Pages 2013
Featured contentOriginal researchEfficacy and Effects on Lipid Metabolism of Combination Treatment With Losartan + Hydrochlorothiazide Versus Losartan + Amlodipine: A 48-Week Prospective, Multicenter, Randomized, Open-Label Trial Fulltext Access 13 Pages 2013
Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers Fulltext Access 14 Pages 2013
Preclinical strategies targeted at non-small-cell lung cancer signalling pathways with striking translational fallout Fulltext Access 14 Pages 2013
Impact of Weight on Treatment Efficacy and Safety in Complicated Skin and Skin Structure Infections and Nosocomial Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus Fulltext Access 14 Pages 2013
Comparison of the Efficacy and Safety of Dual-Opioid Treatment With Morphine Plus Oxycodone Versus Oxycodone/Acetaminophen for Moderate to Severe Acute Pain After Total Knee Arthroplasty Fulltext Access 14 Pages 2013
Electrophysiological and mechanical effects of caffeic acid phenethyl ester, a novel cardioprotective agent with antiarrhythmic activity, in guinea-pig heart Fulltext Access 14 Pages 2013
Optimization and characterization of a rat model of prostate cancer-induced bone pain using behavioral, pharmacological, radiological, histological and immunohistochemical methods Fulltext Access 14 Pages 2013
System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses Fulltext Access 14 Pages 2013
Toxicological and pharmacological concerns on oxidative stress and related diseases Fulltext Access 14 Pages 2013
Development and Evaluation of Paclitaxel Nanoparticles Using a Quality-by-Design Approach Fulltext Access 14 Pages 2013
An Algorithm for Evaluating Potential Tissue Drug Distribution in Toxicology Studies from Readily Available Pharmacokinetic Parameters Fulltext Access 14 Pages 2013
Comparison of In Vitro-In Vivo Extrapolation of Biliary Clearance Using an Empirical Scaling Factor Versus Transport-Based Scaling Factors in Sandwich-Cultured Rat Hepatocytes Fulltext Access 14 Pages 2013
Novel Quality by Design Tools for Concentrated Drug Suspensions: Surface Energy Profiling and the Fractal Concept of Flocculation Fulltext Access 14 Pages 2013
Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice Fulltext Access 14 Pages 2013
Original articleAn evaluation of the non-invasive faecal pellet assessment method as an early drug discovery screen for gastrointestinal liability Fulltext Access 14 Pages 2013
Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit Fulltext Access 14 Pages 2013
Do various baseline characteristics of transversus abdominis and lumbar multifidus predict clinical outcomes in nonspecific low back pain? A systematic review Fulltext Access 14 Pages 2013
Invited reviewEnhancement of cognitive function in models of brain disease through environmental enrichment and physical activity Fulltext Access 14 Pages 2013
Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome Fulltext Access 14 Pages 2013
Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain Fulltext Access 14 Pages 2013
A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: Do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression? Fulltext Access 14 Pages 2013
Original articleDrug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: Effects of reference compounds Fulltext Access 15 Pages 2013
Astrocytic energetics during excitatory neurotransmission: What are contributions of glutamate oxidation and glycolysis? Fulltext Access 15 Pages 2013
Medicinal plant use in two Andean communities located at different altitudes in the BolÃvar Province, Peru Fulltext Access 15 Pages 2013
Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity Fulltext Access 15 Pages 2013
Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish Fulltext Access 15 Pages 2013
Variable maternal stress in rats alters locomotor activity, social behavior, and recognition memory in the adult offspring Fulltext Access 15 Pages 2013
Improved Human Bioavailability of Vemurafenib, a Practically Insoluble Drug, Using an Amorphous Polymer-Stabilized Solid Dispersion Prepared by a Solvent-Controlled Coprecipitation Process Fulltext Access 15 Pages 2013
Antidepressants act directly on astrocytes: Evidences and functional consequences Fulltext Access 15 Pages 2013
The role of inflammatory cytokines in suicidal behavior: A systematic review Fulltext Access 15 Pages 2013
A potential link among biogenic amines-based pesticides, learning and memory, and colony collapse disorder: A unique hypothesis Fulltext Access 15 Pages 2013
Pharmacological evidence of functional inhibitory metabotrophic glutamate receptors on mouse arousal-related cholinergic laterodorsal tegmental neurons Fulltext Access 15 Pages 2013
Expanding Spectrum of Mast Cell Activation Disorders: Monoclonal and Idiopathic Mast Cell Activation Syndromes Fulltext Access 15 Pages 2013
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells Fulltext Access 15 Pages 2013
Diabetes confers a vasoprotective role to the neurocompensatory response elicited by carotid balloon injury: Consequences on contralateral carotid tone and blood flow Fulltext Access 15 Pages 2013
Diabetes updateReview articleNew and Emerging Pharmacologic Therapies for Type 2 Diabetes, Dyslipidemia, and Obesity Fulltext Access 15 Pages 2013
Childhood Obesity: A Review of Increased Risk for Physical and Psychological Comorbidities Fulltext Access 15 Pages 2013
Genes, molecules and patients-Emerging topics to guide clinical pain research Fulltext Access 15 Pages 2013
Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice Fulltext Access 16 Pages 2013
A systematic review and meta-analysis of proton magnetic resonance spectroscopy and mismatch negativity in bipolar disorder Fulltext Access 16 Pages 2013
Investigation of Clinical Pharmacokinetic Variability of an Opioid Antagonist Through Physiologically Based Absorption Modeling Fulltext Access 16 Pages 2013
Application of a Kosmotrope-Based Solubility Assay to Multiple Protein Therapeutic Classes Indicates Broad Use as a High-Throughput Screen for Protein Therapeutic Aggregation Propensity Fulltext Access 16 Pages 2013
Clinical and Economic Assessment of Diabetic Foot Ulcer Debridement with Collagenase: Results of a Randomized Controlled Study Fulltext Access 16 Pages 2013
The pathogenesis of nephropathia epidemica: New knowledge and unanswered questions Fulltext Access 16 Pages 2013
A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity Fulltext Access 16 Pages 2013
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity Fulltext Access 16 Pages 2013
Evidence for working memory deficits in chronic pain: A systematic review and meta-analysis Fulltext Access 16 Pages 2013
Quantitative assessment of biological impact using transcriptomic data and mechanistic network models Fulltext Access 16 Pages 2013
Genetics and iron in the systems biology of Parkinson's disease and some related disorders Fulltext Access 16 Pages 2013
Animal models of chemically induced intestinal inflammation: Predictivity and ethical issues Fulltext Access 16 Pages 2013
Bioprospecting: Evolutionary implications from a post-olmec pharmacopoeia and the relevance of widespread taxa Fulltext Access 16 Pages 2013
Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain Fulltext Access 17 Pages 2013
Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning Fulltext Access 17 Pages 2013
Energy metabolism of cerebral mitochondria during aging, ischemia and post-ischemic recovery assessed by functional proteomics of enzymes Fulltext Access 17 Pages 2013
The hippocampal-prefrontal pathway: The weak link in psychiatric disorders? Fulltext Access 17 Pages 2013
Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson's disease Fulltext Access 17 Pages 2013
Fluticasone/Formoterol Combination Therapy Compared With Monotherapy in Adolescent and Adult Patients With Mild to Moderate Asthma Fulltext Access 17 Pages 2013
Gap-Freezing Approach for Shortening the Lyophilization Cycle Time of Pharmaceutical Formulations-Demonstration of the Concept Fulltext Access 17 Pages 2013
Synaptic plasticity in depression: Molecular, cellular and functional correlates Fulltext Access 17 Pages 2013
Pharmaceutical Nanotechnology Nanoparticle-Based Topical Ophthalmic Formulations for Sustained Celecoxib Release Fulltext Access 18 Pages 2013
Ethnomedicinal plants used for treating epilepsy by indigenous communities of sub-Himalayan region of Uttarakhand, India Fulltext Access 18 Pages 2013
Evaluation of Antiplatelet Agents for Secondary Prevention of Stroke Using Mixed Treatment Comparison Meta-analysis Fulltext Access 18 Pages 2013
Single- and Multiple-Dose Pharmacokinetic, Safety, and Tolerability Profiles of Olanzapine Long-Acting Injection: An Open-Label, Multicenter, Nonrandomized Study in Patients With Schizophrenia Fulltext Access 19 Pages 2013
Estimation of placental and lactational transfer and tissue distribution of atrazine and its main metabolites in rodent dams, fetuses, and neonates with physiologically based pharmacokinetic modeling Fulltext Access 19 Pages 2013
Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury Fulltext Access 20 Pages 2013
Endocannabinoid system and mood disorders: Priming a target for new therapies Fulltext Access 20 Pages 2013
ReviewManagement of diabetic complications: A chemical constituents based approach Fulltext Access 20 Pages 2013
Mixed Treatment Comparison Meta-Analysis of Aspirin, Warfarin, and New Anticoagulants for Stroke Prevention in Patients With Nonvalvular Atrial Fibrillation Fulltext Access 20 Pages 2013
Sandfly-borne phleboviruses of Eurasia and Africa: Epidemiology, genetic diversity, geographic range, control measures Fulltext Access 21 Pages 2013
Vulnerability versus resilience to prenatal stress in male and female rats; Implications from gene expression profiles in the hippocampus and frontal cortex Fulltext Access 21 Pages 2013
Reduced swim performance and aerobic capacity in adult zebrafish exposed to waterborne selenite Fulltext Access 21 Pages 2013
The genus Rhododendron: An ethnopharmacological and toxicological review Fulltext Access 21 Pages 2013
Intracellular pathways of antipsychotic combined therapies: Implication for psychiatric disorders treatment Fulltext Access 22 Pages 2013