کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10588850 981505 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of heterocyclic thiols/thiones eliminated from cephalosporins with iodine and its biological implications
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Interaction of heterocyclic thiols/thiones eliminated from cephalosporins with iodine and its biological implications
چکیده انگلیسی
This study provides the first experimental evidence that the heterocyclic side chains present in cephalosporins not only inhibits peroxidase-catalyzed iodination reactions, but also reacts with iodine to produce stable charge-transfer complexes. The peroxidase inhibition and reactivity toward iodine must be taken into account while designing new antibiotics based on cephalosporins as these activities may adversely affect the thyroid activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 12, 15 June 2010, Pages 3692-3697
نویسندگان
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