کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1362538 | 981490 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Microsomal prostaglandin E2 synthase (mPGES-1) represents a potential target for novel analgesic and anti-inflammatory agents. High-throughput screening identified several leads of mPGES-1 inhibitors which were further optimized for potency and selectivity. A series of inhibitors bearing a biaryl imidazole scaffold exhibits excellent inhibition of PGE2 production in enzymatic and cell-based assays. The synthesis of these molecules and their activities will be discussed.
Biarylimidazoles were prepared and evaluated as inhibitors of microsomal prostaglandin E2 synthase-1.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 23, 1 December 2010, Pages 6978–6982
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 23, 1 December 2010, Pages 6978–6982
نویسندگان
Tom Y.H. Wu, Hélène Juteau, Yves Ducharme, Richard W. Friesen, Sébastien Guiral, Lynn Dufresne, Hugo Poirier, Myriam Salem, Denis Riendeau, Joseph Mancini, Christine Brideau,