کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367189 | 981621 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of novel pyridine-3-propanoic acids was synthesized. A structure–activity relationship study of these compounds led to the identification of potent dual PPARα/γ agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, compounds (S)-14 and (S)-19 were selected for further profiling.
A novel series of potent dual PPARα/γ agonists was identified. SAR studies led to the identification of a multitude of compounds with varied isoform selectivity.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 6120–6123
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 6120–6123
نویسندگان
Paul S. Humphries, Simon Bailey, Jonathon V. Almaden, Sandra J. Barnum, Thomas J. Carlson, Lance C. Christie, Quyen-Quyen T. Do, James D. Fraser, Mary Hess, Jack Kellum, Young H. Kim, Guy A. McClellan, Kathleen M. Ogilvie, Brett H. Simmons,