کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1368785 981726 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of a novel artesunate–podophyllotoxin conjugate as anticancer agent
ترجمه فارسی عنوان
سنتز و ارزیابی بیولوژیکی یک ترکیب آرتسوناتا پودوفیلوتوکسین به عنوان عامل ضد سرطان
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A novel conjugate of artesunate–podophyllotoxin was prepared and evaluated for its cytotoxicity against diverse normal and multidrug resistance human cancer cell lines by CCK-8 assay. The conjugate exhibited good cytotoxicity on all the cell lines with IC50 values of 0.453 ± 0.156–3.011 ± 0.272 μM and reduced the resistant factor. The conjugate was further found to disrupt the microtubule network and induce G2/M cell cycle arrest in multidrug resistance K562/ADR cells. Meanwhile, Hoechst staining analysis suggested that conjugate induced cell death by apoptosis. Furthermore, conjugate could downregulate the levels of P-glycoprotein (P-gp) in P-gp overexpressing K562/ADR cells.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 1, 1 January 2016, Pages 38–42
نویسندگان
, , , , ,