Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chronically infected cells

The anti-HIV-1 activity of GUT-70, a natural product derived from the stem bark of Chlophyllum brasiliense, was evaluated. GUT-70 inhibited HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. Our results strengthen the idea that NF-κB pathway is one of the potential targets to control HIV-1 replication and that GUT-70 could serve as a lead compound to develop novel therapeutic agents against HIV-1 infection.

The tricyclic coumarin, GUT-70 derived from Chlophyllum brasiliense has inhibitory effects against HIV-1 replication in acutely and chronically HIV-1-infected cells via inhibition of the NF-κB.Figure optionsDownload as PowerPoint slide