کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1369398 | 981775 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Naphthalene-based environmentally sensitive fluorescent 8-substituted 2′-deoxyadenosines: Application to DNA detection
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We synthesized various C8-naphthylethynylated 2′-deoxyadenosine derivatives and investigated their photophysical properties. Among them, cyano- and N,N-dimethylamino-substituted 8-naphthylethynylated 2′-deoxyadenosine derivatives (cnA and dnA) showed strong fluorescence with high quantum yields and a remarkable solvatofuorochromicity. In particular, fluorescence of N,N-dimethylamino-substituted 2,6dnA was not quenched by neighboring guanines (Gs) when incorporated in DNA duplexes, in contrast to cnA. We developed a new fluorescent probe containing 2,6dnA that can be used for the detection of target DNA via a bulge formation regardless of the neighboring sequences.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 3, 1 February 2013, Pages 886–892
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 3, 1 February 2013, Pages 886–892
نویسندگان
Azusa Suzuki, Naoya Takahashi, Yuji Okada, Isao Saito, Nobukatsu Nemoto, Yoshio Saito,