کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1369718 981787 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New P2X3 receptor antagonists. Part 2: Identification and SAR of quinazolinones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
New P2X3 receptor antagonists. Part 2: Identification and SAR of quinazolinones
چکیده انگلیسی

Numerous potent P2X3 antagonists have been discovered and the therapeutic potential of P2X3 antagonism already comprises proof-of-concept data obtained in clinical trials with the most advanced compound. We have lately reported the discovery and optimization of thia-triaza-tricycle compounds with potent P2X3 antagonistic properties. This Letter describes the SAR of a back-up series containing a 4-oxo-quinazoline central ring. The discovery of the highly potent compounds 51 is presented.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 16, 15 August 2016, Pages 3905–3912
نویسندگان
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