Complexation of Hypocrellin A with Al3+ in water solution and the photodynamic therapy study

The complex of Hypocrellin A with Al3+ is prepared in water solution by a facile method. The water-solubility and stability of complexes are improved. Irradiation of Al3+–HA complex results in higher efficient generation of singlet oxygen (1O2) and photocleavage ability to CT DNA than HA. In vitro studies have illustrated that the Al3+–HA complex has anti-cancer activity.

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