کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1372289 981868 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure–activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure–activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents
چکیده انگلیسی

The structure–activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 16, 15 August 2013, Pages 4557–4561
نویسندگان
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