کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1372524 | 981871 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovery of inhibitors of plasminogen activator inhibitor-1: Structure–activity study of 5-nitro-2-phenoxybenzoic acid derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Two novel series of 5-nitro-2-phenoxybenzoic acid derivatives are designed as potent PAI-1 inhibitors using hybridization and conformational restriction strategy in the tiplaxtinin and piperazine chemo types. The lead compounds 5a, 6c, and 6e exhibited potent PAI-1 inhibitory activity and favorable oral bioavailability in the rodents.
Two novel series of 5-nitro-2-phenoxybenzoic acid derivatives are designed using hybridization and conformational restriction strategy in the known chemo types as potent and orally bioavailable PAI-1 inhibitors.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 19, 1 October 2011, Pages 5701–5706
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 21, Issue 19, 1 October 2011, Pages 5701–5706
نویسندگان
Vrajesh Pandya, Mukul Jain, Ganes Chakrabarti, Hitesh Soni, Bhavesh Parmar, Balaji Chaugule, Jigar Patel, Jignesh Joshi, Nirav Joshi, Akshyaya Rath, Mehul Raviya, Mubeen Shaikh, Kalapatapu V.V.M. Sairam, Harilal Patel, Pankaj Patel,