کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1375093 | 981932 | 2010 | 4 صفحه PDF | دانلود رایگان |
New manganese(II) complexes of substituted pyridino pentaaza macrocyclic ligands were prepared. The amino-, carboxy-, or other functional groups were placed in the vicinity of the axial position of the metal complex. Their SOD-like activity was determined by cytochrome c assay and compared with one another. The activities of pyridine analogs (12a–b and 13) and m-substituted analogs (12c and 12j) were similar and significantly better than that of the standard compound M-40403. The most potent compound was an o-aminobenzoyl derivative 12i, while the o-carboxybenzoyl analog 12d was the lowest active compound.
The synthesis and SOD-like activity of new manganese(II) complex of substituted pyridino pentaaza macrocyclic ligands are reported.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 20, Issue 8, 15 April 2010, Pages 2421–2424