Design, synthesis, and antibiofilm activity of 2-arylimino-3-aryl-thiazolidine-4-ones

A series of novel 2-arylimino-3-aryl-thiazolidine-4-ones was designed, synthesized and tested for in vitro antibiofilm activity against Staphylococcus epidermidis. Among them tested, some compounds with carboxylic acid groups showed good antibiofilm activity. The antibiofilm concentration of 1x was 6.25 μM. The structure–activity relationships revealed that incorporation of 2-phenylfuran moiety could greatly enhance antibiofilm activity of thiazolidine-4-one.

The minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC) and antibiofilm concentration assay of 1x were 6.25 μM, 25 μM and 6.25 μM against Staphylococcus epidermidis, respectively.Figure optionsDownload as PowerPoint slide