Heterocyclic fused pyridone carboxylic acid M1 positive allosteric modulators

The phenyl ring in a series of quinolone carboxylic acid M1 positive allosteric modulators was replaced with a variety of heterocycles in order to reduce protein plasma binding and enhance CNS exposure.

The phenyl ring in a series of quinolone carboxylic acid M1 positive allosteric modulators was replaced with a variety of heterocycles in order to reduce protein plasma binding and enhance CNS exposure.Figure optionsDownload as PowerPoint slide