Synthesis and antibacterial activity of new 9-O-arylpropenyloxime ketolides

A novel series of 9-O-arylpropenyloxime ketolide was synthesized and evaluated for their antibacterial activity. This series of ketolide exhibited potent activity against clinically isolated gram-positive strains including Staphylococcus pneumoniae and Straptococcus Pyogenes.

New 9-O-arylpropenyloxime ketolides were synthesized and evaluated their antibacterial activities against clinically isolated gram-positive strains. The SAR is discussed.Figure optionsDownload as PowerPoint slide