کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
1375304 981936 2017 5 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Amide analogs of antifungal dioxane–triazole derivatives: Synthesis and in vitro activities
ترجمه فارسی عنوان
مکمل های آمید با مشتقات دی اکسان-آزول ضد قارچ: سنتز و در فعالیت های آزمایشگاهی
کلمات کلیدی
آزول؛ ضد قارچ. آمید با-آنالوگ. ثبات اسید
Triazole; Antifungal; Amide-analog; Acid-stability
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A new series of triazole compounds possessing an amide-part were efficiently synthesized and their in vitro antifungal activities were investigated. The amide analogs showed excellent in vitro activity against Candida, Cryptococcus and Aspergillus species. The MICs of compound 23d against C. albicans ATCC24433, C. neoformans TIMM1855 and A. fumigatus ATCC26430 were ⩽0.008, 0.031 and 0.031 μg/mL, respectively, (MICs of fluconazole: 0.5, >4 and >4 μg/mL; MICs of itraconazole: 0.125, 0.25, 0.25 μg/mL). Furthermore, compound 23d was stable under acidic conditions.

Graphical abstractSynthesis and in vitro antifungal activities of a novel series of triazole antifungal agents wherein the diene part of CS-758 was replaced by an aryl-amide group are described.Figure optionsDownload full-size imageDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 19, Issue 7, 1 April 2009, Pages 2013–2017
نویسندگان
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