Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists

Replacement of the carboxylic acid group in a series of previously described 1,5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high binding efficiency indices.

The discovery and SAR of novel non-acidic 1,5-biaryl pyrrole derivatives is described. Several new motifs were discovered that were found to be effective replacements for the carboxylic acid in a series of EP1 receptor antagonists.Figure optionsDownload as PowerPoint slide