Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3

The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38α is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site.

The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors 4 with selectivity against JNK1 and p38α is reported.Figure optionsDownload as PowerPoint slide