Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists—Increasing selectivity over hERG

Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.

SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity of a series of MCH-R1 antagonists are described.Figure optionsDownload as PowerPoint slide