DNA photocleavage and biological activity of a pyrene dihydrodioxin

A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the ϕX 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.

The title compound has been shown to cleave the ϕX 174 supercoiled plasmid upon photochemical irradiation. It also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.Figure optionsDownload as PowerPoint slide