Internalisation of the μ-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues Fulltext Access 6 Pages 2008
Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase Fulltext Access 6 Pages 2008
Chromen-based TNF-α converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation Fulltext Access 6 Pages 2008
The use of ligand-based de novo design for scaffold hopping and sidechain optimization: Two case studies Fulltext Access 6 Pages 2008
Pyrene–perylene as a FRET pair coupled to the N2′-functionality of 2′-amino-LNA Fulltext Access 6 Pages 2008
Bis-pyrene-labeled molecular beacon: A monomer–excimer switching probe for the detection of DNA base alteration Fulltext Access 6 Pages 2008
Antiproliferative effects of 6-anilino-5-chloro-1H-benzo[d]imidazole-4,7-dione in vascular smooth muscle cells Fulltext Access 6 Pages 2008
Synthesis and inhibitory activity of oligosaccharide thiazolines as a class of mechanism-based inhibitors for endo-β-N-acetylglucosaminidases Fulltext Access 6 Pages 2008
Novel azaphilones, kasanosins A and B, which are specific inhibitors of eukaryotic DNA polymerases β and λ from Talaromyces sp. Fulltext Access 6 Pages 2008
Synthesis and neuropharmacological characterization of 2-O-substituted apomorphines Fulltext Access 6 Pages 2008
Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition Fulltext Access 6 Pages 2008
Benzofused N-substituted cyclic enediynes: Activation and DNA-cleavage potential Fulltext Access 6 Pages 2008
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2) Fulltext Access 6 Pages 2008
Low molecular weight lignin suppresses activation of NF-κB and HIV-1 promoter Fulltext Access 6 Pages 2008
Bornyl (3,4,5-trihydroxy)-cinnamate - An optimized human neutrophil elastase inhibitor designed by free energy calculations Fulltext Access 6 Pages 2008
Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists Fulltext Access 6 Pages 2008
Requirement of β-alanine components in sequence-specific DNA alkylation by pyrrole–imidazole conjugates with seven-base pair recognition Fulltext Access 6 Pages 2008
Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis Fulltext Access 6 Pages 2008
Development of novel β-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole Fulltext Access 6 Pages 2008
2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogs structurally modified by thiocarbamoylalkyl groups at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1 Fulltext Access 6 Pages 2008
BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens Fulltext Access 6 Pages 2008
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold Fulltext Access 6 Pages 2008
Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors Fulltext Access 6 Pages 2008
5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity Fulltext Access 6 Pages 2008
Synthesis of 1,2,3-triazole-linked pyrrolobenzodiazepine conjugates employing ‘click’ chemistry: DNA-binding affinity and anticancer activity Fulltext Access 6 Pages 2008
Orally active esters of dihydroartemisinin: Synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice Fulltext Access 6 Pages 2008
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents Fulltext Access 6 Pages 2008
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine Fulltext Access 6 Pages 2008
Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors Fulltext Access 6 Pages 2008
Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties Fulltext Access 6 Pages 2008
Synthesis and evaluation of PSSRI-based inhibitors of Staphylococcus aureus multidrug efflux pumps Fulltext Access 6 Pages 2008
Discovery of novel inhibitors of 11β-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling Fulltext Access 6 Pages 2008
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity Fulltext Access 6 Pages 2008
3D-QSAR CoMFA studies on bis-coumarine analogues as urease inhibitors: A strategic design in anti-urease agents Fulltext Access 6 Pages 2008
Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors Fulltext Access 6 Pages 2008
8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) Fulltext Access 6 Pages 2008
Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350 Fulltext Access 6 Pages 2008
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase Fulltext Access 6 Pages 2008
Structure–activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands Fulltext Access 6 Pages 2008
Aryl sulfones as novel Bradykinin B1 receptor antagonists for treatment of chronic pain Fulltext Access 6 Pages 2008
Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d]pyrimidines as new bioactive and pharmacological activities Fulltext Access 6 Pages 2008
Quantitative structure–activity relationship studies on 1-aryl-tetrahydroisoquinoline analogs as active anti-HIV agents Fulltext Access 6 Pages 2008
Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions Fulltext Access 6 Pages 2008
Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure–activity relationships of the 1- and 3-positions Fulltext Access 6 Pages 2008
Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis Fulltext Access 6 Pages 2008
Antifungal activity of synthetic di(hetero)arylamines based on the benzo[b]thiophene moiety Fulltext Access 6 Pages 2008
Synthesis and antiproliferative activity in vitro of novel (2-butynyl)thioquinolines Fulltext Access 6 Pages 2008
Syntheses and anti-depressant activity of 5-amino-1, 3, 4-thiadiazole-2-thiol imines and thiobenzyl derivatives Fulltext Access 6 Pages 2008
Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava Fulltext Access 6 Pages 2008
Pestalachlorides A–C, antifungal metabolites from the plant endophytic fungus Pestalotiopsis adusta Fulltext Access 6 Pages 2008
The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine Fulltext Access 6 Pages 2008
Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies Fulltext Access 6 Pages 2008
Synthesis and potent antileukemic activities of 10-benzyl-9(10H)-acridinones Fulltext Access 6 Pages 2008
Conjugates of the fungal cytotoxin illudin M with improved tumour specificity Fulltext Access 6 Pages 2008
The tert-butoxyl radical mediated hydrogen atom transfer reactions of the Parkinsonian proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and selected tertiary amines Fulltext Access 6 Pages 2008
Cyclic diarylheptanoids from Myrica nana inhibiting nitric oxide release Fulltext Access 6 Pages 2008
Synthesis and antitumor activity of C-9 epimers of the tetrahydrofuran containing acetogenin 4-deoxyannoreticuin Fulltext Access 6 Pages 2008
Monoquaternary pyridinium salts with modified side chain—synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase Fulltext Access 6 Pages 2008
Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I–XIV Fulltext Access 6 Pages 2008
Dihydropyridines and atypical MDR: A novel perspective of designing general reversal agents for both typical and atypical MDR Fulltext Access 6 Pages 2008
New terpenoids from Maytenus apurimacensis as MDR reversal agents in the parasite Leishmania Fulltext Access 6 Pages 2008
Imidazo[1,2-a]pyridine derivatives as inhibitors of TNF-α expression in T cells Fulltext Access 6 Pages 2008
Asymmetric synthesis and stereochemical structure–activity relationship of (R)- and (S)-8-[1-(2,4-dichlorophenyl)-2-imidazol-1-yl-ethoxy] octanoic acid heptyl ester, a potent inhibitor of allene oxide synthase Fulltext Access 6 Pages 2008
Electronic effects of para-substitution on acetophenones in the reaction of rat liver 3α-hydroxysteroid dehydrogenase Fulltext Access 6 Pages 2008
Biomimetic synthesis of xuxuarines Eα and Eβ: Structure revision of Rzedowskia bistriterpenoids Fulltext Access 6 Pages 2008
Orally active 1,2,4-trioxepanes: Synthesis and antimalarial activity of a series of 7-arylvinyl-1,2,4-trioxepanes against multidrug-resistant Plasmodium yoelii in Swiss mice Fulltext Access 6 Pages 2008
Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity Fulltext Access 6 Pages 2008
Enhanced affinity of ketotifen toward tamarind seed polysaccharide in comparison with hydroxyethylcellulose and hyaluronic acid: A nuclear magnetic resonance investigation Fulltext Access 6 Pages 2008
Structure and biological activity of novel FN analogs as flowering inducers Fulltext Access 6 Pages 2008
Novel nitroheterocyclic hypoxic markers for solid tumor: Synthesis and biological evaluation Fulltext Access 6 Pages 2008
Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors Fulltext Access 6 Pages 2008
Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling Fulltext Access 6 Pages 2008
1-Deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae Fulltext Access 6 Pages 2008
DNA polymerase bypass in vitro and in E. coli of a C-nucleotide analogue of Fapy·dG Fulltext Access 6 Pages 2008
Synthesis of eudistomin D analogues and its effects on adenosine receptors Fulltext Access 6 Pages 2008
Synthesis and anti-cancer activity of benzothiazole containing phthalimide on human carcinoma cell lines Fulltext Access 6 Pages 2008
N-Aroyl-3,5-bis(benzylidene)-4-piperidones: A novel class of antimycobacterial agents Fulltext Access 6 Pages 2008
Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A Fulltext Access 6 Pages 2008
Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols Fulltext Access 6 Pages 2008
Hanultarin, a cytotoxic lignan as an inhibitor of actin cytoskeleton polymerization from the seeds of Trichosanthes kirilowii Fulltext Access 6 Pages 2008
Hetero-Diels–Alder reaction of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with arylsulfonylcyanides. Synthesis and antimicrobial activity of 4-hydroxy-2-(arylsulfonyl)pyridines Fulltext Access 6 Pages 2008
Synthesis of new heteroaryl and heteroannulated indoles from dehydrophenylalanines: Antitumor evaluation Fulltext Access 6 Pages 2008
Design and synthesis of dinucleotide 5′-triphosphates with expanded functionality Fulltext Access 6 Pages 2008
Simplified fast and high yielding automated synthesis of [18F]fluoroethylcholine for prostate cancer imaging Fulltext Access 6 Pages 2008
3-Amino-2(5H)furanones as inhibitors of subgenomic hepatitis C virus RNA replication Fulltext Access 6 Pages 2008
Pestaloficiols A–E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici Fulltext Access 6 Pages 2008
Selection of phage-displayed peptides that bind to a particular ligand-bound antibody Fulltext Access 6 Pages 2008
A peptoid antagonist of VEGF Receptor 2 recognizes a ‘hotspot’ in the extracellular domain distinct from the hormone-binding site Fulltext Access 6 Pages 2008