Carbonic anhydrase inhibitors: Interactions of phenols with the 12 catalytically active mammalian isoforms (CA I–XIV) Fulltext Access 5 Pages 2008
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity Fulltext Access 5 Pages 2008
An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity Fulltext Access 5 Pages 2008
Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides Fulltext Access 5 Pages 2008
BACE1 inhibitors: Optimization by replacing the P1′ residue with non-acidic moiety Fulltext Access 5 Pages 2008
Synthesis of hybrid acetogenins, α,β-unsaturated-γ-lactone-free nitrogen-containing heterocyclic analogues, and their cytotoxicity against human cancer cell lines Fulltext Access 5 Pages 2008
A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy Fulltext Access 5 Pages 2008
Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold Fulltext Access 5 Pages 2008
Structure-activity relationships of 2-chloro-N6-substituted-4â²-thioadenosine-5â²-N,N-dialkyluronamides as human A3 adenosine receptor antagonists Fulltext Access 5 Pages 2008
Use of the X-ray structure of the Beta2-adrenergic receptor for drug discovery Fulltext Access 5 Pages 2008
Synthesis and biological evaluation of trimethyl-substituted cap analogs Fulltext Access 5 Pages 2008
Individual stereoisomers of phosphinic dipeptide inhibitor of leucine aminopeptidase Fulltext Access 5 Pages 2008
Substrate specificity and screening of the integral membrane protease Pla Fulltext Access 5 Pages 2008
Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor Fulltext Access 5 Pages 2008
1-Hydroxy-2-pyridinone-based MMP inhibitors: Synthesis and biological evaluation for the treatment of ischemic stroke Fulltext Access 5 Pages 2008
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors Fulltext Access 5 Pages 2008
Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as γ-secretase inhibitors Fulltext Access 5 Pages 2008
Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors Fulltext Access 5 Pages 2008
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: Trends across multiple chemical series Fulltext Access 5 Pages 2008
Uncovering false positives on a virtual screening search for cruzain inhibitors Fulltext Access 5 Pages 2008
Synthetic study of VLA-4/VCAM-1 inhibitors: Synthesis and structure-activity relationship of piperazinylphenylalanine derivatives Fulltext Access 5 Pages 2008
Discovery and SAR of 1,3,4-thiadiazole derivatives as potent Abl tyrosine kinase inhibitors and cytodifferentiating agents Fulltext Access 5 Pages 2008
N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR Fulltext Access 5 Pages 2008
Synthesis and antimicrobial activity of novel C-linked imidazole glycoconjugates Fulltext Access 5 Pages 2008
Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action Fulltext Access 5 Pages 2008
Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity Fulltext Access 5 Pages 2008
β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 1. Design, synthesis, and lead identification Fulltext Access 5 Pages 2008
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 2. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists Fulltext Access 5 Pages 2008
Chemical resolution of (±)-calanolide A, (±)-cordatolide A and their 11-demethyl analogues Fulltext Access 5 Pages 2008
Design and synthesis of 4-[(s-triazin-2-ylamino)methyl]-N-(2-aminophenyl)-benzamides and their analogues as a novel class of histone deacetylase inhibitors Fulltext Access 5 Pages 2008
Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents Fulltext Access 5 Pages 2008
BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells Fulltext Access 5 Pages 2008
BACE-1 inhibitors part 2: Identification of hydroxy ethylamines (HEAs) with reduced peptidic character Fulltext Access 5 Pages 2008
Identifying the important structural elements of brominated furanones for inhibiting biofilm formation by Escherichia coli Fulltext Access 5 Pages 2008
Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists Fulltext Access 5 Pages 2008
Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues Fulltext Access 5 Pages 2008
Hybrid angiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles Fulltext Access 5 Pages 2008
Synthesis and structure–activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases Fulltext Access 5 Pages 2008
Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents Fulltext Access 5 Pages 2008
Lysinyl macrocyclic hexaoxazoles: Synthesis and selective G-quadruplex stabilizing properties Fulltext Access 5 Pages 2008
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-Fused and hetero-fused systems Fulltext Access 5 Pages 2008
Synthesis and antimicrobial activity of β-lactam–bile acid conjugates linked via triazole Fulltext Access 5 Pages 2008
Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors Fulltext Access 5 Pages 2008
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors Fulltext Access 5 Pages 2008
Novel CADD-based peptidyl vinyl ester derivatives as potential proteasome inhibitors Fulltext Access 5 Pages 2008
Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization Fulltext Access 5 Pages 2008
Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation Fulltext Access 5 Pages 2008
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R) Fulltext Access 5 Pages 2008
Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization Fulltext Access 5 Pages 2008
Discovery of a novel class of 1,3-dioxane-2-carboxylic acid derivatives as subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists Fulltext Access 5 Pages 2008
Synthesis and biological properties of β-turned Aβ31–35 constrained analogues Fulltext Access 5 Pages 2008
An asymmetric C8/C8′-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs Fulltext Access 5 Pages 2008
Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles Fulltext Access 5 Pages 2008
Structure and property based design of factor Xa inhibitors: Pyrrolidin-2-ones with biaryl P4 motifs Fulltext Access 5 Pages 2008
Capillary zone electrophoresis for separation and analysis of four diarylheptanoids and an α-tetralone derivative in the green walnut husks (Juglans regia L.) Fulltext Access 5 Pages 2008
Chromatographic behavior of zwitterionic enalapril—Exploring the conditions for lipophilicity assessment Fulltext Access 5 Pages 2008
Utility of cyclodextrins in the formulation of genistein: Part 1. Preparation and physicochemical properties of genistein complexes with native cyclodextrins Fulltext Access 5 Pages 2008
Validated HPTLC methods for the determination of salicin in Salix sp. and of harpagoside in Harpogophytum procumbens Fulltext Access 5 Pages 2008
Investigation of mass-balance issue in e-beam sterilized paclitaxel eluting coronary stents by SPME/GC-MS Fulltext Access 5 Pages 2008
Pharmacokinetics of amoxicillin in human urine using online coupled capillary electrophoresis with electrogenerated chemiluminescence detection Fulltext Access 5 Pages 2008
Liquid chromatographic–tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma Fulltext Access 5 Pages 2008
Bioequivalence study of bromhexine by liquid chromatography–electrospray ionization-mass spectrometry after oral administration of bromhexine hydrochloride tablets Fulltext Access 5 Pages 2008
High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats Fulltext Access 5 Pages 2008
Quantitative determination of spinosin in rat plasma by liquid chromatography-tandem mass spectrometry method Fulltext Access 5 Pages 2008
Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis Fulltext Access 5 Pages 2008
Substituted 2-oxo-azepane derivatives are potent, orally active γ-secretase inhibitors Fulltext Access 5 Pages 2008
Design, synthesis, and in vitro photodynamic activities of benzochloroporphyrin derivatives as tumor photosensitizers Fulltext Access 5 Pages 2008
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Optimising brain penetration Fulltext Access 5 Pages 2008
Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists Fulltext Access 5 Pages 2008
Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors Fulltext Access 5 Pages 2008
Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor Fulltext Access 5 Pages 2008
Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors Fulltext Access 5 Pages 2008
Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds Fulltext Access 5 Pages 2008
Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties Fulltext Access 5 Pages 2008
Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: On the significance of the orientation and substitution at position 3 Fulltext Access 5 Pages 2008
Extraction and determination of 2-pyrazoline derivatives using liquid phase microextraction based on solidification of floating organic drop Fulltext Access 5 Pages 2008
Development of CXCR3 antagonists. Part 3: Tropenyl and homotropenyl-piperidine urea derivatives Fulltext Access 5 Pages 2008
Diastereoselective synthesis of (R)-(alkyl)-β-d-galactopyranoside by using β-galactosidase (Aspergillus oryzae) in low-water media Fulltext Access 5 Pages 2008
Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex Fulltext Access 5 Pages 2008
Antimicrobial activities of the bromophenols from the red alga Odonthalia corymbifera and some synthetic derivatives Fulltext Access 5 Pages 2008
Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine Fulltext Access 5 Pages 2008
1-Toluene-sulfonyl-3-[(3′-hydroxy-5′-substituted)-γ-butyrolactone]-indoles: Synthesis, COX-2 inhibition and anti-cancer activities Fulltext Access 5 Pages 2008
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity Fulltext Access 5 Pages 2008
Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones Fulltext Access 5 Pages 2008
Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors Fulltext Access 5 Pages 2008