Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase Fulltext Access 5 Pages 2008
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors Fulltext Access 5 Pages 2008
Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition Fulltext Access 5 Pages 2008
Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists Fulltext Access 5 Pages 2008
Design and campaign synthesis of pyridine-based histone deacetylase inhibitors Fulltext Access 5 Pages 2008
An efficient one-pot synthesis of tethered cyclohexadiene enaminonitriles from methyl-ketones: An effective route to quinazolines Fulltext Access 5 Pages 2008
Functionalization of the 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) core Fulltext Access 5 Pages 2008
Top-down mass spectrometry on low-resolution instruments: Characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways Fulltext Access 5 Pages 2008
Synthesis and analysis of a fluorinated product analogue as an inhibitor for 1-deoxy-d-xylulose 5-phosphate reductoisomerase Fulltext Access 5 Pages 2008
A set of phosphatase-inert “molecular rulers” to probe for bivalent mannose 6-phosphate ligand–receptor interactions Fulltext Access 5 Pages 2008
Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin Fulltext Access 5 Pages 2008
Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B Fulltext Access 5 Pages 2008
Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors Fulltext Access 5 Pages 2008
Synthesis of 5″-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca2+-mobilizing agent: The first antagonists modified at the N1-ribose moiety Fulltext Access 5 Pages 2008
Dopamine/serotonin receptor ligands. Part 17: A cross-target SAR approach: Affinities of azecine-styled ligands for 5-HT2A versus D1 and D2 receptors Fulltext Access 5 Pages 2008
Preliminary in vivo evaluation of a novel 99mTc-Labeled HYNIC-cys-annexin A5 as an apoptosis imaging agent Fulltext Access 5 Pages 2008
Design, synthesis, and structure–activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine Fulltext Access 5 Pages 2008
Pyrrolo[2,1-c][1,4]benzodiazepine-β-glucuronide prodrugs with a potential for selective therapy of solid tumors by PMT and ADEPT strategies Fulltext Access 5 Pages 2008
2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A β-lactamase BS3 of Bacillus licheniformis Fulltext Access 5 Pages 2008
Synthesis and biological activities of reveromycin A and spirofungin A derivatives Fulltext Access 5 Pages 2008
Discovery and biological evaluation of novel α-glucosidase inhibitors with in vivo antidiabetic effect Fulltext Access 5 Pages 2008
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design Fulltext Access 5 Pages 2008
Discovery of potent, orally active benzimidazole glucagon receptor antagonists Fulltext Access 5 Pages 2008
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists Fulltext Access 5 Pages 2008
4-Amino-2-cyanopyrimidines: Novel scaffold for nonpeptidic cathepsin S inhibitors Fulltext Access 5 Pages 2008
A novel peptide from α5 helix of Asterina pectinifera cyclin B conjugated to HIV-Tat49-57 with cytotoxic and apoptotic effects against human cancer cells Fulltext Access 5 Pages 2008
4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase Fulltext Access 5 Pages 2008
4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors Fulltext Access 5 Pages 2008
Aminoquinazolines as TRPV1 antagonists: Modulation of drug-like properties through the exploration of 2-position substitution Fulltext Access 5 Pages 2008
Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination Fulltext Access 5 Pages 2008
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties Fulltext Access 5 Pages 2008
Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists Fulltext Access 5 Pages 2008
N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1) Fulltext Access 5 Pages 2008
Studies on the structure–activity relationship of bicifadine analogs as monoamine transporter inhibitors Fulltext Access 5 Pages 2008
Development of 2-tbutyl-N-methyl pyrimidones as potent inhibitors of HIV integrase Fulltext Access 5 Pages 2008
Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold Fulltext Access 5 Pages 2008
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors Fulltext Access 5 Pages 2008
A novel bifunctional maleimido CHX-A″ chelator for conjugation to thiol-containing biomolecules Fulltext Access 5 Pages 2008
2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: Optimization via array synthesis Fulltext Access 5 Pages 2008
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds Fulltext Access 5 Pages 2008
Hypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia Fulltext Access 5 Pages 2008
4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing Fulltext Access 5 Pages 2008
Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity Fulltext Access 5 Pages 2008
Antioxidant capacity of human blood plasma and human urine: Simultaneous evaluation of the ORAC index and ascorbic acid concentration employing pyrogallol red as probe Fulltext Access 5 Pages 2008
Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy Fulltext Access 5 Pages 2008
Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones Fulltext Access 5 Pages 2008
Halicyclamine A, a marine spongean alkaloid as a lead for anti-tuberculosis agent Fulltext Access 5 Pages 2008
Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the α-aminoadipate pathway Fulltext Access 5 Pages 2008
Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer Fulltext Access 5 Pages 2008
Chemical synthesis of scyllo-inosamine and catabolism studies in Sinorhizobium meliloti Fulltext Access 5 Pages 2008
Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase Fulltext Access 5 Pages 2008
Ratiometric multimodal chemosensors based on cubic silsesquioxanes for monitoring solvent polarity Fulltext Access 5 Pages 2008
Petiolins A–C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum Fulltext Access 5 Pages 2008
Evaluation of ligand-binding affinity using polynomial empirical scoring functions Fulltext Access 5 Pages 2008
Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers Fulltext Access 5 Pages 2008
Identification of neomycin B-binding site in T box antiterminator model RNA Fulltext Access 5 Pages 2008
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II Fulltext Access 5 Pages 2008
Axial chirality and affinity at the GABAA receptor of pyrimido[1,2-a][1,4]benzodiazepines and related compounds Fulltext Access 5 Pages 2008
Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana Fulltext Access 5 Pages 2008
Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase Fulltext Access 5 Pages 2008
Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis Fulltext Access 5 Pages 2008
Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity Fulltext Access 5 Pages 2008
Synthesis and bio-evaluation of a new fatty acid derivative for myocardial imaging Fulltext Access 5 Pages 2008
Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis Fulltext Access 5 Pages 2008
Cytotoxic bromotyrosine derivatives from a two-sponge association of Jaspis sp. and Poecillastra sp. Fulltext Access 5 Pages 2008
Synthesis and structure–activity relationship of benzetimide derivatives as human CXCR3 antagonists Fulltext Access 5 Pages 2008
Synthesis and biological evaluation of the Zn (II)-IDB complexes appended with oligopolyamide as potent artificial nuclease Fulltext Access 5 Pages 2008
Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors Fulltext Access 5 Pages 2008
Tetrakis-azaaromatic quaternary ammonium salts: Novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release Fulltext Access 5 Pages 2008
New classes of Gram-positive selective antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis Fulltext Access 5 Pages 2008
N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists Fulltext Access 5 Pages 2008
Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines Fulltext Access 5 Pages 2008
Peptide deformylase inhibitors of Mycobacterium tuberculosis: Synthesis, structural investigations, and biological results Fulltext Access 5 Pages 2008
Synthesis of trans-caffeate analogues and their bioactivities against HIV-1 integrase and cancer cell lines Fulltext Access 5 Pages 2008
Synthesis and biological evaluation of homopiperazine derivatives with β-aminoacyl group as dipeptidyl peptidase IV inhibitors Fulltext Access 5 Pages 2008
Modulation of PPAR receptor subtype selectivity of the ligands: Aliphatic chain vs aromatic ring as a spacer between pharmacophore and the lipophilic moiety Fulltext Access 5 Pages 2008
The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing Fulltext Access 5 Pages 2008
Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists Fulltext Access 5 Pages 2008
Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors Fulltext Access 5 Pages 2008
Carbonic anhydrase inhibitors. Inhibition of the β-class enzyme from the yeast Saccharomyces cerevisiae with anions Fulltext Access 5 Pages 2008
Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality Fulltext Access 5 Pages 2008
Antitumor effects of curcumin and structurally β-diketone modified analogs on multidrug resistant cancer cells Fulltext Access 5 Pages 2008
Chemotherapeutic bone-targeted bisphosphonate prodrugs with hydrolytic mode of activation Fulltext Access 5 Pages 2008
Design of a pyrene-containing fluorescence probe for labeling of RNA poly(A) tracts Fulltext Access 5 Pages 2008
The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans Fulltext Access 5 Pages 2008
Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids Fulltext Access 5 Pages 2008