Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase Fulltext Access 6 Pages 2008
Design, synthesis, FGF-1 binding, and molecular modeling studies of conformationally flexible heparin mimetic disaccharides Fulltext Access 6 Pages 2008
Synthesis, characterization and DNA-binding properties of four Zn(II) complexes with bis(pyrrol-2-yl-methyleneamine) ligands Fulltext Access 6 Pages 2008
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure–activity relationship elucidation Fulltext Access 6 Pages 2008
Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors Fulltext Access 6 Pages 2008
Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells Fulltext Access 6 Pages 2008
Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone Fulltext Access 6 Pages 2008
2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents Fulltext Access 6 Pages 2008
The expedient synthesis of 1,5-benzothiazepines as a family of cytotoxic drugs Fulltext Access 6 Pages 2008
New ultra-short acting hypnotic: Synthesis, biological evaluation, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124) Fulltext Access 6 Pages 2008
Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines Fulltext Access 6 Pages 2008
Preparation and in vitro biological evaluation of tetrapyrrole ethanolamide derivatives as potential anticancer agents Fulltext Access 6 Pages 2008
Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity Fulltext Access 6 Pages 2008
Structure and property based design of factor Xa inhibitors: Biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs Fulltext Access 6 Pages 2008
Synthesis and antimicrobial activity of 3-arylamino-1-chloropropan-2-ols Fulltext Access 6 Pages 2008
Synthesis and biological evaluation of 5-(pyridin-2-yl)thiazoles as transforming growth factor-β type1 receptor kinase inhibitors Fulltext Access 6 Pages 2008
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists Fulltext Access 6 Pages 2008
Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors Fulltext Access 6 Pages 2008
Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain Fulltext Access 6 Pages 2008
Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues Fulltext Access 6 Pages 2008
Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists Fulltext Access 6 Pages 2008
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K Fulltext Access 6 Pages 2008
Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor Fulltext Access 6 Pages 2008
Synthesis and biological activity of novel peptide mimetics as melanocortin receptor agonists Fulltext Access 6 Pages 2008
In silico screening and biological evaluation of inhibitors of Src-SH3 domain interaction with a proline-rich ligand Fulltext Access 6 Pages 2008
Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors Fulltext Access 6 Pages 2008
β-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: Part 2. Optimization of α-amino substituents Fulltext Access 6 Pages 2008
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail Fulltext Access 6 Pages 2008
Protected aminooxyprolines for expedited library synthesis: Application to Tsg101-directed proline–oxime containing peptides Fulltext Access 6 Pages 2008
Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation Fulltext Access 6 Pages 2008
BACE-1 inhibitors Part 1: Identification of novel hydroxy ethylamines (HEAs) Fulltext Access 6 Pages 2008
Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker Fulltext Access 6 Pages 2008
Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2) Fulltext Access 6 Pages 2008
Bioisosteric replacement of dihydropyrazole of 4S-(−)-3-(4-chlorophenyl)-N-methyl-N′-[(4-chlorophenyl)-sulfonyl]-4-phenyl-4,5-dihydro-1H-pyrazole-1-caboxamidine (SLV-319) a potent CB1 receptor antagonist by imidazole and oxazole Fulltext Access 6 Pages 2008
Design and synthesis of dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole oximes as potent dual inhibitors of TIE-2 and VEGF-R2 receptor tyrosine kinases Fulltext Access 6 Pages 2008
The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: A novel series of CRF-1 receptor antagonists Fulltext Access 6 Pages 2008
Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists Fulltext Access 6 Pages 2008
2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924 Fulltext Access 6 Pages 2008
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands Fulltext Access 6 Pages 2008
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARα/γ agonists. Part I: Synthesis and pharmacological evaluation Fulltext Access 6 Pages 2008
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-α Converting Enzyme (TACE): Novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1′ substituents Fulltext Access 6 Pages 2008
Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi Fulltext Access 6 Pages 2008
Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines Fulltext Access 6 Pages 2008
Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A Fulltext Access 6 Pages 2008
Robust Raman measurement of hydrogen peroxide directly through plastic containers under the change of bottle position and its long-term prediction reproducibility Fulltext Access 6 Pages 2008
Optimised sample handling in association with use of the CMA 600 analyser Fulltext Access 6 Pages 2008
An improved LC–ESI–MS–MS method for simultaneous quantitation of rosiglitazone and N-desmethyl rosiglitazone in human plasma Fulltext Access 6 Pages 2008
Simultaneous determination of vancomycin and ceftazidime in cerebrospinal fluid in craniotomy patients by high-performance liquid chromatography Fulltext Access 6 Pages 2008
Simultaneous determination of amoxicillin and ambroxol in human plasma by LC–MS/MS: Validation and application to pharmacokinetic study Fulltext Access 6 Pages 2008
Semi-preparative HPLC preparation and HPTLC quantification of tetrahydroamentoflavone as marker in Semecarpus anacardium and its polyherbal formulations Fulltext Access 6 Pages 2008
Multiresponse optimization of the properties of albendazole–chitosan microparticles Fulltext Access 6 Pages 2008
Chemical composition and antioxidant activity of volatiles from Patrinia Villosa Juss obtained by optimized supercritical fluid extraction Fulltext Access 6 Pages 2008
Liquid chromatographic analysis of guanidino compounds using furoin as a new fluorogenic reagent Fulltext Access 6 Pages 2008
Antibody-based enzyme-linked lectin assay (ABELLA) for the sialylated recombinant human erythropoietin present in culture supernatant Fulltext Access 6 Pages 2008
Quantification of pegylated phospholipids decorating polymeric microcapsules of perfluorooctyl bromide by reverse phase HPLC with a charged aerosol detector Fulltext Access 6 Pages 2008
Quenching of α,β-unsaturated aldehydes by green tea polyphenols: HPLC–ESI–MS/MS studies Fulltext Access 6 Pages 2008
Establishment of a liquid chromatographic/mass spectrometry method for quantification of tetrandrine in rat plasma and its application to pharmacokinetic study Fulltext Access 6 Pages 2008
Alkaloid profiling of crude and processed Veratrum nigrum L. through simultaneous determination of ten steroidal alkaloids by HPLC–ELSD Fulltext Access 6 Pages 2008
Qualitative and quantitative analysis of flavonoids in the leaves of Isatis indigatica Fort. by ultra-performance liquid chromatography with PDA and electrospray ionization tandem mass spectrometry detection Fulltext Access 6 Pages 2008
An approach based on HPLC-fingerprint and chemometrics to quality consistency evaluation of Liuwei Dihuang Pills produced by different manufacturers Fulltext Access 6 Pages 2008
Simultaneous determination of a hydrophobic drug candidate and its metabolite in human plasma with salting-out assisted liquid/liquid extraction using a mass spectrometry friendly salt Fulltext Access 6 Pages 2008
An improved HPLC method with fluorescence detection for the determination of pyrene in rat plasma and its pharmacokinetics Fulltext Access 6 Pages 2008
Quantitative determination of clopidogrel active metabolite in human plasma by LC–MS/MS Fulltext Access 6 Pages 2008
Electroanalytical properties of a novel biosensor modified with zirconium alcoxide porous gels for the detection of acetaminophen Fulltext Access 6 Pages 2008
Simultaneous determination of lansoprazole and its metabolites 5′-hydroxy lansoprazole and lansoprazole sulphone in human plasma by LC–MS/MS: Application to a pharmacokinetic study in healthy volunteers Fulltext Access 6 Pages 2008
Development of an HPLC method for the determination of tetranortriterpenoids in Carapa guianensis seed oil by experimental design Fulltext Access 6 Pages 2008
Development of an HPLC-DAD–ESI-MSn method for quantitative analysis of Saussurea tridactyla Fulltext Access 6 Pages 2008
Structural elucidation of a PDE-5 inhibitor detected as an adulterant in a health supplement Fulltext Access 6 Pages 2008
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties Fulltext Access 6 Pages 2008
Identification and optimization of a novel series of [2.2.1]-oxabicyclo imide-based androgen receptor antagonists Fulltext Access 6 Pages 2008
Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity Fulltext Access 6 Pages 2008
Carbonic anhydrase inhibitors: The very weak inhibitors dithiothreitol, β-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX Fulltext Access 6 Pages 2008
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases Fulltext Access 6 Pages 2008
Phenylethynyl-pyrrolo[1,2-a]pyrazine: A new potent and selective tool in the mGluR5 antagonists arena Fulltext Access 6 Pages 2008
Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists Fulltext Access 6 Pages 2008
The design and synthesis of novel α-ketoamide-based p38 MAP kinase inhibitors Fulltext Access 6 Pages 2008
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)—A potent and efficacious p38α MAP kinase inhibitor Fulltext Access 6 Pages 2008
2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors Fulltext Access 6 Pages 2008
Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca2+-activated K+ channel blockers Fulltext Access 6 Pages 2008
The discovery of fused pyrrole carboxylic acids as novel, potent d-amino acid oxidase (DAO) inhibitors Fulltext Access 6 Pages 2008
5-Aryluracils as potent GnRH antagonists—Characterization of atropisomers Fulltext Access 6 Pages 2008
Synthesis and anti-Helicobacter pylori activity of 5-(nitroaryl)-1,3,4-thiadiazoles with certain sulfur containing alkyl side chain Fulltext Access 6 Pages 2008
Effects of amide constituents from pepper on adipogenesis in 3T3-L1 cells Fulltext Access 6 Pages 2008
Synthesis and antitumor activity of benzils related to combretastatin A-4 Fulltext Access 6 Pages 2008
Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators Fulltext Access 6 Pages 2008
Prediction models of human plasma protein binding rate and oral bioavailability derived by using GA–CG–SVM method Fulltext Access 6 Pages 2008
Simultaneous determination of five main active constituents of Erigeron multiradiatus by HPLC-DAD-MS Fulltext Access 6 Pages 2008