1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors Fulltext Access 4 Pages 2005
Discovery of a novel, potent and selective human β3-adrenergic receptor agonist Fulltext Access 4 Pages 2005
Crystallographic determination of stereochemistry of biologically active 2â³,3â³-dibromo-7-epi-10-deacetylcephalomannine Fulltext Access 4 Pages 2005
Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies Fulltext Access 4 Pages 2005
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors Fulltext Access 4 Pages 2005
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships Fulltext Access 4 Pages 2005
Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT7 receptor Fulltext Access 4 Pages 2005
Design and synthesis of macrocycles active against vancomycin-resistant enterococci (VRE): the interplay between d-Ala-d-Lac binding and hydrophobic effect Fulltext Access 4 Pages 2005
A new ligand binding to G-G mismatch having improved thermal and alkaline stability Fulltext Access 4 Pages 2005
Active site directed inhibitors of replication-specific bacterial DNA polymerases Fulltext Access 4 Pages 2005
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans Fulltext Access 4 Pages 2005
Pyrenyldiazomethane, a versatile reagent for nucleotide phosphate alkylation Fulltext Access 4 Pages 2005
Synthesis and antifungal activity of noble 5-arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles Fulltext Access 4 Pages 2005
Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase Fulltext Access 4 Pages 2005
Cleavage at 5-methylcytosine in DNA by photosensitized oxidation with 2-methyl-1,4-naphthoquinone tethered oligodeoxynucleotides Fulltext Access 4 Pages 2005
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold Fulltext Access 4 Pages 2005
Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands Fulltext Access 4 Pages 2005
Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells Fulltext Access 4 Pages 2005
Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis Fulltext Access 4 Pages 2005
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme Fulltext Access 4 Pages 2005
Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists Fulltext Access 4 Pages 2005
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives Fulltext Access 4 Pages 2005
Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors Fulltext Access 4 Pages 2005
(S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity Fulltext Access 4 Pages 2005
Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus Fulltext Access 4 Pages 2005
Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier Fulltext Access 4 Pages 2005
Structure-antioxidant activity relationships of flavonoids isolated from the resinous exudate of Heliotropium sinuatum Fulltext Access 4 Pages 2005
Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups Fulltext Access 4 Pages 2005
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers Fulltext Access 4 Pages 2005
The discovery and synthesis of novel adenosine receptor (A2A) antagonists Fulltext Access 4 Pages 2005
Structure-activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor α/β agonist scaffold Fulltext Access 4 Pages 2005
Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors Fulltext Access 4 Pages 2005
Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic Fulltext Access 4 Pages 2005
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists Fulltext Access 4 Pages 2005
Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle system Fulltext Access 4 Pages 2005
Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol Fulltext Access 4 Pages 2005
Biaryls and heterobiaryls as α-glucosidase and protein tyrosine phosphatase inhibitors Fulltext Access 4 Pages 2005
Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors Fulltext Access 4 Pages 2005
4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands Fulltext Access 4 Pages 2005
Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics Fulltext Access 4 Pages 2005
Synthesis and radiopharmacological evaluation of 2â²-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET) Fulltext Access 4 Pages 2005
Lipidic carriers of RNA/DNA oligonucleotides and polynucleotides: What a difference a formulation makes! Fulltext Access 4 Pages 2005
Enantiomerical excess determination, purification and biological evaluation of (3S) and (3R) α,β-butenolide analogues of isobenzofuranone Fulltext Access 4 Pages 2005
The discovery of a selective, high affinity A2B adenosine receptor antagonist for the potential treatment of asthma Fulltext Access 4 Pages 2005
Studies on the structure-activity relationship of 2â²,6â²-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH3 Fulltext Access 4 Pages 2005
Generation of a new class of hNK2 receptor ligands using the 'fragment approach' Fulltext Access 4 Pages 2005
Synthesis of modified proanthocyanidins: easy and general introduction of a hydroxy group at C-6 of catechin; efficient synthesis of elephantorrhizol Fulltext Access 4 Pages 2005
Synthesis of modified proanthocyanidins: introduction of acyl substituents at C-8 of catechin. Selective synthesis of a C-4 â O â C-3 ether-linked procyanidin-like dimer Fulltext Access 4 Pages 2005
Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists Fulltext Access 4 Pages 2005
Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B Fulltext Access 4 Pages 2005
Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity Fulltext Access 4 Pages 2005
Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T Fulltext Access 4 Pages 2005
2-Substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one as a structurally new NK1 antagonist Fulltext Access 4 Pages 2005
Crystal structures of human HSP90α-complexed with dihydroxyphenylpyrazoles Fulltext Access 4 Pages 2005
Electronic structure calculations on the thiazole-containing antibiotic thiostrepton: molecular mechanics, semi-empirical and ab initio analyses Fulltext Access 4 Pages 2005
Transcorneal and transscleral iontophoresis of dexamethasone phosphate using drug loaded hydrogel Fulltext Access 5 Pages 2005
Preliminary assessment of carrageenan as excipient for extrusion/spheronisation Fulltext Access 5 Pages 2005
Observations in simultaneous microencapsulation of 5-fluorouracil and leucovorin for combined pH-dependent release Fulltext Access 5 Pages 2005
The influence of bile salts and mixed micelles on the pharmacokinetics of quinine in rabbits Fulltext Access 5 Pages 2005
Delivery aspects of small peptides and substrates for peptide transporters Fulltext Access 5 Pages 2005
Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds Fulltext Access 5 Pages 2005
Uptake of fluorescein isothiocyanate-labelled dextran into the CSF after intranasal and intravenous administration to rats Fulltext Access 5 Pages 2005
Non-invasive pulmonary aerosol delivery in mice by the endotracheal route Fulltext Access 5 Pages 2005
Cellular fate of oligonucleotides when delivered by nanocapsules of poly(isobutylcyanoacrylate) Fulltext Access 5 Pages 2005