A physicogenetic method to assign ligand-binding relationships between 7TM receptors Fulltext Access 6 Pages 2005
Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity Fulltext Access 6 Pages 2005
A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice Fulltext Access 6 Pages 2005
Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid Fulltext Access 6 Pages 2005
Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents Fulltext Access 6 Pages 2005
Potential new antitumor agents from an innovative combination of camphorato, a ramification of traditional Chinese medicine, with a platinum moiety Fulltext Access 6 Pages 2005
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors Fulltext Access 6 Pages 2005
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties Fulltext Access 6 Pages 2005
Structure–activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities Fulltext Access 6 Pages 2005
QSAR analyses of conformationally restricted 1,5-diaryl pyrazoles as selective COX-2 inhibitors: application of connection table representation of ligands Fulltext Access 6 Pages 2005
Benzothiazolium compounds: novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFNγ Fulltext Access 6 Pages 2005
Bicyclic nucleoside inhibitors of Varicella–Zoster virus: The effect of branching in the p-alkylphenyl side chain Fulltext Access 6 Pages 2005
Design, synthesis and structure–activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae Fulltext Access 6 Pages 2005
1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists Fulltext Access 6 Pages 2005
Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists Fulltext Access 6 Pages 2005
A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides—a new zinc-binding function in the design of inhibitors Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies Fulltext Access 6 Pages 2005
Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole Fulltext Access 6 Pages 2005
Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase Fulltext Access 6 Pages 2005
Indole- and indoline-based kainate analogues with antagonist activity at ionotropic glutamate receptors Fulltext Access 6 Pages 2005
A linear discrimination analysis based virtual screening of trichomonacidal lead-like compounds: Outcomes of in silico studies supported by experimental results Fulltext Access 6 Pages 2005
Structure-based design and synthesis of pyrazinones containing novel P1 ‘side pocket’ moieties as inhibitors of TF/VIIa Fulltext Access 6 Pages 2005
Cancer preventive agents. Part 1: Chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds Fulltext Access 6 Pages 2005
Antioxidant activity of differently regioselective chitosan sulfates in vitro Fulltext Access 6 Pages 2005
On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I-DNA covalent binary complex Fulltext Access 6 Pages 2005
Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity Fulltext Access 6 Pages 2005
Technetium-99m labelled integrated tropane-BAT as a potential dopamine transporter tracer Fulltext Access 6 Pages 2005
A theoretical study on the structure-activity relationships of metabolites of folates as antioxidants and its implications for rational design of antioxidants Fulltext Access 6 Pages 2005
Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c]phenanthridine-type alkaloid, and its structure-activity relationship, studied by X-ray crystal structure analysis and molecular docking study Fulltext Access 6 Pages 2005
Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole–imidazole polyamides Fulltext Access 6 Pages 2005
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff’s bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: Inhibition of the transmembrane isozyme XIV with sulfonamides Fulltext Access 6 Pages 2005
Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator Fulltext Access 6 Pages 2005
In pursuit of α4β2 nicotinic receptor partial agonists for smoking cessation: Carbon analogs of (−)-cytisine Fulltext Access 6 Pages 2005
Discovery and structure–activity relationships of novel sulfonamides as potent PTP1B inhibitors Fulltext Access 6 Pages 2005
Synthesis and antipicornavirus activity of (R)- and (S)-1-[5-(4′-chlorobiphenyl-4-yloxy)-3-methylpentyl]-3-pyridin-4-yl-imidazolidin-2-one Fulltext Access 6 Pages 2005
Identification of ortho-amino benzamides and nicotinamides as MCHr1 antagonists Fulltext Access 6 Pages 2005
Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists Fulltext Access 6 Pages 2005
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase Fulltext Access 6 Pages 2005
Exploring the connection unit in the HDAC inhibitor pharmacophore model: Novel uracil-based hydroxamates Fulltext Access 6 Pages 2005
Radical scavenging activity of protein from tentacles of jellyfish Rhopilema esculentum Fulltext Access 6 Pages 2005
Recognition of a 10 base pair sequence of DNA and stereochemical control of the binding affinity of chiral hairpin polyamide–Hoechst 33258 conjugates Fulltext Access 6 Pages 2005
Synthesis and monoamine transporter affinity of 3-aryl substituted trop-2-enes Fulltext Access 6 Pages 2005
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors Fulltext Access 6 Pages 2005
Metalloform-selective inhibition: Synthesis and structure–activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase Fulltext Access 6 Pages 2005
3-N,N-Dimethylamino-3-deoxy lincomycin: A structure-based hybrid between lincomycin and the desosamine unit of erythromycin Fulltext Access 6 Pages 2005
Symbioimine and neosymbioimine, amphoteric iminium metabolites from the symbiotic marine dinoflagellate Symbiodinium sp. Fulltext Access 6 Pages 2005
On the mechanism of isomerization of all-trans-retinol esters to 11-cis-retinol in retinal pigment epithelial cells: 11-Fluoro-all-trans-retinol as substrate/inhibitor in the visual cycle Fulltext Access 6 Pages 2005
New 1,2,3,4-tetrahydro-1-aza-anthraquinones and 2-aminoalkyl compounds from norlapachol with molluscicidal activity Fulltext Access 6 Pages 2005
3D-QSAR analysis on benzazole derivatives as eukaryotic topoisomerase II inhibitors by using comparative molecular field analysis method Fulltext Access 6 Pages 2005
Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells Fulltext Access 6 Pages 2005
Synthesis of selective SRPK-1 inhibitors: Novel tricyclic quinoxaline derivatives Fulltext Access 6 Pages 2005
QSAR studies of paeonol analogues for inhibition of platelet aggregation Fulltext Access 6 Pages 2005
Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides Fulltext Access 6 Pages 2005
Novel synthetic isoquinolino[5,4-ab]phenazines: Inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities Fulltext Access 6 Pages 2005
Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives Fulltext Access 6 Pages 2005
QSAR of the testosterone binding globulin affinity by means of correlation weighting of local invariants of the graph of atomic orbitals Fulltext Access 6 Pages 2005
2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT Inhibitors Fulltext Access 6 Pages 2005
Multifunctional action of antifungal polygodial against Saccharomyces cerevisiae: Involvement of pyrrole formation on cell surface in antifungal action Fulltext Access 6 Pages 2005
Isolation, characterization and biological evaluation of datura lactones as potential immunomodulators Fulltext Access 6 Pages 2005
New clerodane diterpenoids from Laetia procera (Poepp.) Eichler (Flacourtiaceae), with antiplasmodial and antileishmanial activities Fulltext Access 6 Pages 2005
Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1 Fulltext Access 6 Pages 2005
Privileged structure based ligands for melanocortin receptors—Substituted benzylic piperazine derivatives Fulltext Access 6 Pages 2005
Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine Fulltext Access 6 Pages 2005
Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives Fulltext Access 6 Pages 2005
Determination of human serum albumin using an intramolecular charge transfer fluorescence probe: 4â²-Dimethylamino-2,5-dihydroxychalcone Fulltext Access 6 Pages 2005
Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5 Fulltext Access 6 Pages 2005
Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors Fulltext Access 6 Pages 2005
Design and syntheses of melanocortin subtype-4 receptor agonists. Part 2: Discovery of the dihydropyridazinone motif Fulltext Access 6 Pages 2005
Interaction of cromolyn sodium with human serum albumin: A fluorescence quenching study Fulltext Access 6 Pages 2005
Reduced cardiac side-effect potential by introduction of polar groups: Discovery of NIBR-1282, an orally bioavailable CCR5 antagonist which is active in vivo Fulltext Access 6 Pages 2005
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity Fulltext Access 6 Pages 2005
Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides Fulltext Access 6 Pages 2005
Quantitative structure-activity relationship studies for antioxidant hydroxybenzalacetones by quantum chemical- and 3-D-QSAR(CoMFA) analyses Fulltext Access 6 Pages 2005
Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid Fulltext Access 6 Pages 2005
Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity Fulltext Access 6 Pages 2005
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents Fulltext Access 6 Pages 2005
Design, synthesis, and biological evaluation of novel 4-hydroxypyrone derivatives as HIV-1 protease inhibitors Fulltext Access 6 Pages 2005