Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands Fulltext Access 6 Pages 2006
Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors Fulltext Access 6 Pages 2006
Structure–activity relationships of novel antibacterial translation inhibitors: 3,5-Diamino-piperidinyl triazines Fulltext Access 6 Pages 2006
Identification of substituted 4-aminopiperidines and 3-aminopyrrolidines as potent MCH-R1 antagonists for the treatment of obesity Fulltext Access 6 Pages 2006
Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors Fulltext Access 6 Pages 2006
Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements Fulltext Access 6 Pages 2006
Synthesis and structure–activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents Fulltext Access 6 Pages 2006
Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers Fulltext Access 6 Pages 2006
Electrochemiluminescence determination of pipemidic acid using sulfite as energy transfer mediator Fulltext Access 6 Pages 2006
Ureas with histamine H3-antagonist receptor activity—A new scaffold discovered by lead-hopping from cinnamic acid amides Fulltext Access 6 Pages 2006
Improved 3D-QSAR CoMFA of the dopamine transporter blockers with multiple conformations using the genetic algorithm Fulltext Access 6 Pages 2006
Design, synthesis, and preliminary biological evaluation of novel ethyl 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carboxylate Fulltext Access 6 Pages 2006
Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations Fulltext Access 6 Pages 2006
3D-QSAR studies of farnesyltransferase inhibitors: A comparative molecular field analysis approach Fulltext Access 7 Pages 2006
Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385 Fulltext Access 7 Pages 2006
Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated α-carbonic anhydrase from Helicobacter pylori Fulltext Access 7 Pages 2006
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2′-Substituted triclosan derivatives Fulltext Access 7 Pages 2006
Design and synthesis of potent β-secretase (BACE1) inhibitors with P1′ carboxylic acid bioisosteres Fulltext Access 7 Pages 2006
Synthesis and evaluation of succinoyl-caprolactam γ-secretase inhibitors Fulltext Access 7 Pages 2006
Design, synthesis, antibacterial, and QSAR studies of myristic acid derivatives Fulltext Access 7 Pages 2006
New ligand-based approach for the discovery of antitrypanosomal compounds Fulltext Access 7 Pages 2006
Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors Fulltext Access 7 Pages 2006
A novel naturally occurring tripyrrole with potential nuclease and anti-tumour properties Fulltext Access 7 Pages 2006
Kinetic investigation on aqueous decomposition of 2-chloroethylnitrososulfamide Fulltext Access 7 Pages 2006
3D-QSAR studies on antitubercular thymidine monophosphate kinase inhibitors based on different alignment methods Fulltext Access 7 Pages 2006
The synthesis and aqueous superoxide anion scavenging of water-dispersible lutein esters Fulltext Access 7 Pages 2006
Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation Fulltext Access 7 Pages 2006
Depeptidization efforts on P3–P2′ α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity Fulltext Access 7 Pages 2006
Nuphar alkaloids with immediately apoptosis-inducing activity from Nuphar pumilum and their structural requirements for the activity Fulltext Access 7 Pages 2006
Synthesis, X-ray crystallographic analysis, and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-α-aminophosphonates Fulltext Access 7 Pages 2006
Orally active thrombin inhibitors. Part 1: Optimization of the P1-moiety Fulltext Access 7 Pages 2006
Identification and characterization of amino-piperidinequinolones and quinazolinones as MCHr1 antagonists Fulltext Access 7 Pages 2006
CA224, a non-planar analogue of fascaplysin, inhibits Cdk4 but not Cdk2 and arrests cells at G0/G1 inhibiting pRB phosphorylation Fulltext Access 7 Pages 2006
3D QSAR studies of N-4-arylacryloylpiperazin-1-yl-phenyl-oxazolidinones: A novel class of antibacterial agents Fulltext Access 7 Pages 2006
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: A new class of CDK2 inhibitors Fulltext Access 7 Pages 2006
The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate Fulltext Access 7 Pages 2006
Synthesis and in vitro evaluation of salvinorin A analogues: Effect of configuration at C(2) and substitution at C(18) Fulltext Access 7 Pages 2006
Cyclopentane-based human NK1 antagonists. Part 1: Discovery and initial SAR Fulltext Access 7 Pages 2006
PET imaging and optical imaging with d-luciferin [11C]methyl ester and d-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice Fulltext Access 7 Pages 2006
New tyrosinase inhibitors selected by atomic linear indices-based classification models Fulltext Access 7 Pages 2006
Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures Fulltext Access 7 Pages 2006
1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of bloo Fulltext Access 7 Pages 2006
The influence of pH on the G-quadruplex binding selectivity of perylene derivatives Fulltext Access 7 Pages 2006
Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation Fulltext Access 7 Pages 2006
Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849 Fulltext Access 7 Pages 2006
SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849 Fulltext Access 7 Pages 2006
Inhibitors of VEGF receptors-1 and -2 based on the 2-((pyridin-4-yl)ethyl)pyridine template Fulltext Access 7 Pages 2006
Structural basis for DNA-cleaving activity of resveratrol in the presence of Cu(II) Fulltext Access 7 Pages 2006
Reduction of nonspecific binding proteins to self-assembled monolayer on gold surface Fulltext Access 7 Pages 2006
Search for dual function inhibitors for Alzheimer’s disease: Synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Aβ fibril formation inhibition capacity Fulltext Access 7 Pages 2006
Synthesis and in vitro antitumoral activity of new hydrazinopyrimidine-5-carbonitrile derivatives Fulltext Access 7 Pages 2006
QSAR studies of N1-(5-chloro-2-pyridyl)-2-{[4-(alkyl methyl)benzoyl]amino}-5-chlorobenzamide analogs Fulltext Access 7 Pages 2006
Structural characteristics of novel symmetrical diaryl derivatives with nitrogenated functions. Requirements for cytotoxic activity Fulltext Access 7 Pages 2006
Synthesis and antibacterial activity of some new 1-heteroaryl-5-amino-3H/methyl-4-phenylpyrazoles Fulltext Access 7 Pages 2006
Ribonucleic guanidine demonstrates an unexpected marked preference for complementary DNA rather than RNA Fulltext Access 7 Pages 2006
Evaluation of aldose reductase inhibition and docking studies of some secondary metabolites, isolated from Origanum vulgare L. ssp. hirtum Fulltext Access 7 Pages 2006
Activity of lupane triterpenoids from Maytenus species as inhibitors of nitric oxide and prostaglandin E2 Fulltext Access 7 Pages 2006
The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides Fulltext Access 7 Pages 2006
Design, synthesis, and evaluation of novel galloyl pyrrolidine derivatives as potential anti-tumor agents Fulltext Access 7 Pages 2006
Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA Fulltext Access 7 Pages 2006
Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone derivatives Fulltext Access 7 Pages 2006
Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells. Is there a correlation between binding affinity to NBD of P-gp and modulation of transport? Fulltext Access 7 Pages 2006
Synthesis and antiproliferative activity of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles Fulltext Access 7 Pages 2006
Synthesis of 8-aminoadenosine 5′-(aminoalkyl phosphates), analogues of aminoacyl adenylates Fulltext Access 7 Pages 2006
Synthesis and binding affinities of methylvesamicol analogs for the acetylcholine transporter and sigma receptor Fulltext Access 7 Pages 2006
Synthesis, antiproliferative and antifungal activities of some 2-(2,4-dihydroxyphenyl)-4H-3,1-benzothiazines Fulltext Access 7 Pages 2006
Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes Fulltext Access 7 Pages 2006
Synthesis and in vitro anti-hepatitis B virus activities of some ethyl 5-hydroxy-1H-indole-3-carboxylates Fulltext Access 7 Pages 2006
Synthesis, stereochemical assignments, and biological activities of homoisoflavonoids Fulltext Access 7 Pages 2006
Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines Fulltext Access 7 Pages 2006
Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure Fulltext Access 7 Pages 2006
DNA sequence recognition in the minor groove by hairpin microgonotropens Fulltext Access 7 Pages 2006
Fish venom (Pterios volitans) peptide reduces tumor burden and ameliorates oxidative stress in Ehrlich's ascites carcinoma xenografted mice Fulltext Access 7 Pages 2006
DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine Fulltext Access 7 Pages 2006
Enhancing effect of indirubin derivatives on 1,25-dihydroxyvitamin D3- and all-trans retinoic acid-induced differentiation of HL-60 leukemia cells Fulltext Access 7 Pages 2006
Synthesis and DNA cleavage activities of mononuclear macrocyclic polyamine zinc(II), copper(II), cobalt(II) complexes which linked with uracil Fulltext Access 7 Pages 2006
New progesterone receptor antagonists: Phosphorus-containing 11β-aryl-substituted steroids Fulltext Access 7 Pages 2006
2-(4,5-Dihydroimidazol-2-yl)benzimidazoles as highly selective imidazoline I2/adrenergic α2 receptor ligands Fulltext Access 7 Pages 2006
Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine Fulltext Access 7 Pages 2006
Membrane interaction of amphotericin B as single-length assembly examined by solid state NMR for uniformly 13C-enriched agent Fulltext Access 7 Pages 2006
In silico modeling of protein tyrosine phosphatase 1B inhibitors with cellular activity Fulltext Access 7 Pages 2006
The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase Fulltext Access 7 Pages 2006
Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities Fulltext Access 7 Pages 2006
Synthesis and antiproliferative evaluation of certain pyrido[3,2-g]quinoline derivatives Fulltext Access 7 Pages 2006
Structure–activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum Fulltext Access 7 Pages 2006
Synthesis of novel vasodilatory active nicotinate esters with amino acid function Fulltext Access 7 Pages 2006
Synthesis and evaluation of peptidic irreversible inhibitors of tissue transglutaminase Fulltext Access 7 Pages 2006
Structure of C-terminal fragment of merozoite surface protein-1 from Plasmodium vivax determined by homology modeling and molecular dynamics refinement Fulltext Access 7 Pages 2006
Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analog Fulltext Access 7 Pages 2006
Antioxidant properties of violacein: Possible relation on its biological function Fulltext Access 7 Pages 2006
Effect of melanin on netilmicin-induced inhibition of collagen biosynthesis in human skin fibroblasts Fulltext Access 7 Pages 2006