Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies Fulltext Access 6 Pages 2006
Synthesis and anthelmintic activity of substituted (R)-phenyllactic acid containing cyclohexadepsipeptides Fulltext Access 6 Pages 2006
Modeling and synthesis of non-cyclic derivatives of GPI-1046 as potential FKBP ligands with neurotrophic properties Fulltext Access 6 Pages 2006
The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production Fulltext Access 6 Pages 2006
β-Secretase inhibitors: Modification at the P4 position and improvement of inhibitory activity in cultured cells Fulltext Access 6 Pages 2006
Structure–activity relationships of triazolopyridine oxazole p38 inhibitors: Identification of candidates for clinical development Fulltext Access 6 Pages 2006
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors Fulltext Access 6 Pages 2006
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors Fulltext Access 6 Pages 2006
Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors Fulltext Access 6 Pages 2006
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists Fulltext Access 6 Pages 2006
Dithiocarbamic acid esters as anticancer agent. Part 1: 4-Substituted-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl esters Fulltext Access 6 Pages 2006
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors Fulltext Access 6 Pages 2006
Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as anticancer and X syndrome disease therapeutic agents Fulltext Access 6 Pages 2006
Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability Fulltext Access 6 Pages 2006
Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring Fulltext Access 6 Pages 2006
Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa Fulltext Access 6 Pages 2006
DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides Fulltext Access 6 Pages 2006
Design and synthesis of heterocyclic malonyl-CoA decarboxylase inhibitors Fulltext Access 6 Pages 2006
Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase Fulltext Access 6 Pages 2006
Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5′-ribofuran-uronamide moiety Fulltext Access 6 Pages 2006
Isolation and inhibitory activity against ERK Phosphorylation of hydroxyanthraquinones from rhubarb Fulltext Access 6 Pages 2006
Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists Fulltext Access 6 Pages 2006
Fungal metabolites of xanthohumol with potent antiproliferative activity on human cancer cell lines in vitro Fulltext Access 6 Pages 2006
Development and in vitro efficacy of novel MMP2 and MMP9 specific doxorubicin albumin conjugates Fulltext Access 6 Pages 2006
6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: Structure–activity exploration of eastern and western parts Fulltext Access 6 Pages 2006
Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives Fulltext Access 6 Pages 2006
Microwave-assisted synthesis of N-alkylated benzotriazole derivatives: Antimicrobial studies Fulltext Access 6 Pages 2006
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists Fulltext Access 6 Pages 2006
Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Fulltext Access 6 Pages 2006
Pyridobenzodiazepines: A novel class of orally active, vasopressin V2 receptor selective agonists Fulltext Access 6 Pages 2006
Novel fluorescent labelled affinity probes for diadenosine-5′,5‴-P1,P4-tetraphosphate (Ap4A)-binding studies Fulltext Access 6 Pages 2006
Highly potent and selective zwitterionic agonists of the δ-opioid receptor. Part 1 Fulltext Access 6 Pages 2006
Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC Fulltext Access 6 Pages 2006
Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure–activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine Fulltext Access 6 Pages 2006
Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines Fulltext Access 6 Pages 2006
Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2 Fulltext Access 6 Pages 2006
Anticancer activity of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane Fulltext Access 6 Pages 2006
Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase Fulltext Access 6 Pages 2006
The water-soluble fullerene derivative ‘Radical Sponge®’ exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes Fulltext Access 6 Pages 2006
Synthesis of (2E)-3-{2-[(substituted benzyl)oxy]phenyl}acrylaldehydes as novel anti-inflammatory agents Fulltext Access 6 Pages 2006
Synthesis and structure–activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors Fulltext Access 6 Pages 2006
Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus Fulltext Access 6 Pages 2006
Orally active thrombin inhibitors. Part 2: Optimization of the P2-moiety Fulltext Access 6 Pages 2006
Monitoring the neuropeptide metabolites by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry Fulltext Access 6 Pages 2006
Augmentation of near infrared diffuse reflectance and transmittance spectral data for the development of robust PLSBC models for classifying double blind clinical trial tablets Fulltext Access 6 Pages 2006
Simple determination of the HIV protease inhibitor atazanavir in human plasma by high-performance liquid chromatography with UV detection Fulltext Access 6 Pages 2006
Enhancement of an analytical method for the determination of squalene in anthrax vaccine adsorbed formulations Fulltext Access 6 Pages 2006
High performance liquid chromatography – tandem mass spectrometric determination of cyclovirobuxine D in human plasma Fulltext Access 6 Pages 2006
Detection of budesonide in human urine after inhalation by liquid chromatography–mass spectrometry Fulltext Access 6 Pages 2006
Integration of a rapid automated solubility classification into early validation of hits obtained by high throughput screening Fulltext Access 6 Pages 2006
A new approach to quantitative NMR: Fluoroquinolones analysis by evaluating the chemical shift displacements Fulltext Access 6 Pages 2006
Quantitative determination of gatifloxacin, levofloxacin, lomefloxacin and pefloxacin fluoroquinolonic antibiotics in pharmaceutical preparations by high-performance liquid chromatography Fulltext Access 6 Pages 2006
A rapid and simple determination of protoberberine alkaloids in cortex phellodendri by 1H NMR and its application for quality control of commercial traditional Chinese medicine prescriptions Fulltext Access 6 Pages 2006
Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry Fulltext Access 6 Pages 2006
A simple spectrophotometric method for the determination of β-blockers in dosage forms Fulltext Access 6 Pages 2006
Anisoin: A useful pre-chromatographic derivatization fluorogenic reagent for LC analysis of guanidino compounds Fulltext Access 6 Pages 2006
Preparation and characterization of inclusion complexes of prazosin hydrochloride with β-cyclodextrin and hydroxypropyl-β-cyclodextrin Fulltext Access 6 Pages 2006
Stir bar sorptive extraction with in situ de-conjugation and thermal desorption gas chromatography-mass spectrometry for measurement of 4-nonylphenol glucuronide in human urine sample Fulltext Access 6 Pages 2006
Micellar electrokinetic chromatography for separation of a mixture of coptis alkaloids, scute flavonoids, and rhubarb anthraquinones and bianthrones Fulltext Access 6 Pages 2006
Capillary electrophoretic method for the determination of diterpenoid isomers in Acanthopanax species Fulltext Access 6 Pages 2006
Determination of bifendate in human plasma by HPLC–MS and bioequivalence on bifendate pills in healthy volunteers Fulltext Access 6 Pages 2006
Quantification of huperzine A in Huperzia serrata by HPLC-UV and identification of the major constituents in its alkaloid extracts by HPLC-DAD-MS-MS Fulltext Access 6 Pages 2006
Liquid chromatography–negative ion electrospray tandem mass spectrometry method for the quantification of ezetimibe in human plasma Fulltext Access 6 Pages 2006
HPLC determination of lincomycin in premixes and feedstuffs with solid-phase extraction on HLB OASIS and LC–MS/MS confirmation Fulltext Access 6 Pages 2006
Development of an HPLC method for the analysis of Apomine in a topical cream formulation Fulltext Access 6 Pages 2006
Application of constant-current coulometry for estimation of plasma total antioxidant capacity and its relationship with transition metal contents Fulltext Access 6 Pages 2006
Solid phase extraction and liquid chromatographic determination of sildenafil and N-demethylsidenafil in rat serum with basic mobile phase Fulltext Access 6 Pages 2006
A novel oxazine ring closure reaction affording (Z)-((E)-2-styrylbenzo[b]furo[3,2-d][1,3]oxazin-4-ylideno)acetaldehydes and their anti-osteoclastic bone resorption activity Fulltext Access 6 Pages 2006
Antioxidant activity and cytoprotective effect of κ-carrageenan oligosaccharides and their different derivatives Fulltext Access 6 Pages 2006
A topological function based on spectral moments for predicting affinity toward A3 adenosine receptors Fulltext Access 6 Pages 2006
The cytotoxicity of ortho alkyl substituted 4-X-phenols: A QSAR based on theoretical bond lengths and electron densities Fulltext Access 6 Pages 2006
Heteropoly acids as solid green Brønsted acids for a one-pot synthesis of β-acetamido ketones by Dakin–West reaction Fulltext Access 6 Pages 2006
Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines Fulltext Access 6 Pages 2006
Convenient synthesis of 3- and 6-deoxy-d-myo-inositol phosphate analogues from (+)-epi- and (−)-vibo-quercitols Fulltext Access 6 Pages 2006
Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers Fulltext Access 6 Pages 2006
Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis Fulltext Access 6 Pages 2006
Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa Fulltext Access 6 Pages 2006
Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors Fulltext Access 6 Pages 2006
4′-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3′,4′,5′-substituted)anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule agents Fulltext Access 6 Pages 2006
Sequential-injection determination of traces of disodium phenyl dibenzimidazole tetrasulphonate in urine from users of sunscreens by on-line solid-phase extraction coupled with a fluorimetric detector Fulltext Access 6 Pages 2006
The synthesis and SAR of 2-amino-pyrrolo[2,3-d]pyrimidines: A new class of Aurora-A kinase inhibitors Fulltext Access 6 Pages 2006
Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers Fulltext Access 6 Pages 2006
Novel imidazole-based combretastatin A-4 analogues: Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin Fulltext Access 6 Pages 2006
New rifabutin analogs: Synthesis and biological activity against Mycobacterium tuberculosis Fulltext Access 6 Pages 2006
Distachyasin: A new antioxidant metabolite from the leaves of Carex distachya Fulltext Access 6 Pages 2006
Inhibition of Tpl2 kinase and TNFα production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis Fulltext Access 6 Pages 2006
Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands Fulltext Access 6 Pages 2006
Synthesis and antihyperlipidemic activity of novel glycosyl fructose derivatives Fulltext Access 6 Pages 2006
Comparative protein modeling and surface analysis of Leishmania sirtuin: A potential target for antileishmanial drug discovery Fulltext Access 6 Pages 2006
Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug Fulltext Access 6 Pages 2006
Bioluminescent bacteria assay of veterinary drugs in excreta of food-producing animals Fulltext Access 6 Pages 2006