Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B Fulltext Access 6 Pages 2005
Effects of short-term treatment with vitamin E in systemic sclerosis: a double blind, randomized, controlled clinical trial of efficacy based on urinary isoprostane measurement Fulltext Access 6 Pages 2005
High sensitivity enzyme-linked immunosorbent assay (ELISA) method for measuring protein carbonyl in samples with low amounts of protein Fulltext Access 6 Pages 2005
Autoantibodies against oxidized LDL are associated with severe chest pain attacks in patients with coronary heart disease Fulltext Access 6 Pages 2005
Synthesis of a library of benzoindolizines using poly(ethylene glycol) as soluble support Fulltext Access 6 Pages 2005
A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX Fulltext Access 6 Pages 2005
Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives Fulltext Access 6 Pages 2005
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists Fulltext Access 6 Pages 2005
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors Fulltext Access 6 Pages 2005
1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR Fulltext Access 6 Pages 2005
A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists Fulltext Access 6 Pages 2005
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates Fulltext Access 6 Pages 2005
New conformationally locked bicyclic N,O-nucleoside analogues of antiviral drugs Fulltext Access 6 Pages 2005
Identification of putative metabolites of docosahexaenoic acid as potent PPARγ agonists and antidiabetic agents Fulltext Access 6 Pages 2005
3,4-Disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity Fulltext Access 6 Pages 2005
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction Fulltext Access 6 Pages 2005
Design and synthesis of novel 9-substituted-7-aryl-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]- and [2,3-b]-1,5-oxazocin-6-ones as NK1 antagonists Fulltext Access 6 Pages 2005
Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists Fulltext Access 6 Pages 2005
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase Fulltext Access 6 Pages 2005
Involvement of ATP synthase residues αArg-376, βArg-182, and βLys-155 in Pi binding Fulltext Access 6 Pages 2005
Space as the final frontier in stochastic simulations of biological systems Fulltext Access 6 Pages 2005
Space in systems biology of signaling pathways - towards intracellular molecular crowding in silico Fulltext Access 6 Pages 2005
Persistent TNF-α exposure impairs store operated calcium influx in CD4+ T lymphocytes Fulltext Access 6 Pages 2005
SHARP-2/Stra13/DEC1 as a potential repressor of phosphoenolpyruvate carboxykinase gene expression Fulltext Access 6 Pages 2005
Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions Fulltext Access 6 Pages 2005
Inhibition of human telomerase by oligonucleotide chimeras, composed of an antisense moiety and a chemically modified homo-oligonucleotide Fulltext Access 6 Pages 2005
Ser475, Glu272, Asp276, Asp327, and Asp360 are involved in catalytic activity of human tripeptidyl-peptidase I Fulltext Access 6 Pages 2005
Screening of genes expressed in developing mandibles during soldier differentiation in the termite Hodotermopsis sjostedti Fulltext Access 6 Pages 2005
GC-MS libraries for the rapid identification of metabolites in complex biological samples Fulltext Access 6 Pages 2005
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity Fulltext Access 6 Pages 2005
HCO3--independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes Fulltext Access 6 Pages 2005
A novel octameric AMP-forming acetyl-CoA synthetase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum Fulltext Access 6 Pages 2005
Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14 Fulltext Access 6 Pages 2005
GABA shunt deficiencies and accumulation of reactive oxygen intermediates: insight from Arabidopsis mutants Fulltext Access 6 Pages 2005
2-Aminoperimidine, a specific inhibitor of bacterial NhaA Na+/H+ antiporters Fulltext Access 6 Pages 2005
Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins Fulltext Access 6 Pages 2005
Constitutive activity of Sauromatum guttatum alternative oxidase in Schizosaccharomyces pombe implicates residues in addition to conserved cysteines in α-keto acid activation Fulltext Access 6 Pages 2005
One- and two-photon photoactivation of a paGFP-fusion protein in live Drosophila embryos Fulltext Access 6 Pages 2005
A multicolor fluorescence immunostaining technique for simultaneous antigen targeting Fulltext Access 6 Pages 2005
Histological and histochemical assessment of the effects of a single dose adriamycin on fetal rat kidney Fulltext Access 6 Pages 2005
Tobamovirus-resistant tobacco generated by RNA interference directed against host genes Fulltext Access 6 Pages 2005
Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides Fulltext Access 6 Pages 2005
Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2 Fulltext Access 6 Pages 2005
Evaluation of nuclear transfer and transcription of plasmid DNA condensed with protamine by microinjection: The use of a nuclear transfer score Fulltext Access 6 Pages 2005
Expression of tau reduces secretion of Aβ without altering the amyloid precursor protein content in CHOsw cells Fulltext Access 6 Pages 2005
Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1) Fulltext Access 6 Pages 2005
The low energy emitting states of the Lhca4 subunit of higher plant photosystem I Fulltext Access 6 Pages 2005
Functional role of AMP-activated protein kinase in the heart during exercise Fulltext Access 6 Pages 2005
In vitro selection of DNA binding sites for ABF1 protein from Saccharomyces cerevisiae Fulltext Access 6 Pages 2005
Gelatin binding to the 8F19F1 module pair of human fibronectin requires site-specific N-glycosylation Fulltext Access 6 Pages 2005
Crystal structure of a mutant elongation factor G trapped with a GTP analogue Fulltext Access 6 Pages 2005
Identification of the reactive cysteine residues in oligopeptidase B from Trypanosoma brucei Fulltext Access 6 Pages 2005
Silencing of NbECR encoding a putative enoyl-CoA reductase results in disorganized membrane structures and epidermal cell ablation in Nicotiana benthamiana Fulltext Access 6 Pages 2005
Maximin 9, a novel free thiol containing antimicrobial peptide with antimycoplasma activity from frog Bombina maxima Fulltext Access 6 Pages 2005
Regulation of uncoupling protein activity in phosphorylating potato tuber mitochondria Fulltext Access 6 Pages 2005
Water channel activities of Mimosa pudica plasma membrane intrinsic proteins are regulated by direct interaction and phosphorylation Fulltext Access 6 Pages 2005
Staphylococcal enterotoxin A modulates intracellular Ca2+ signal pathway in human intestinal epithelial cells Fulltext Access 6 Pages 2005
The role of firefly luciferase C-terminal domain in efficient coupling of adenylation and oxidative steps Fulltext Access 6 Pages 2005
The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity Fulltext Access 6 Pages 2005
Theoretical model of the interactions between Ca2+, calmodulin and myosin light chain kinase Fulltext Access 6 Pages 2005
Blastocladiella emersonii expresses a centrin similar to Chlamydomonas reinhardtii isoform not found in late-diverging fungi Fulltext Access 6 Pages 2005
Superoxide determines nitric oxide uptake rate by vascular smooth muscle cells Fulltext Access 6 Pages 2005
Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides Fulltext Access 6 Pages 2005
Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives Fulltext Access 6 Pages 2005
N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP Fulltext Access 6 Pages 2005
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle Fulltext Access 6 Pages 2005
Synthesis and in vitro study of novel Mannich bases as antibacterial agents Fulltext Access 6 Pages 2005
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase Fulltext Access 6 Pages 2005
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties Fulltext Access 6 Pages 2005
Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase) Fulltext Access 6 Pages 2005
Combinatorial approaches towards the discovery of new tryptase inhibitors Fulltext Access 6 Pages 2005
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II Fulltext Access 6 Pages 2005
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13) Fulltext Access 6 Pages 2005
Conformational analysis of rhazinilam and three-dimensional quantitative structure-activity relationships of rhazinilam analogues Fulltext Access 6 Pages 2005
Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA) Fulltext Access 6 Pages 2005
Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists Fulltext Access 6 Pages 2005
Molecular docking of the highly hypolipidemic agent α-asarone with the catalytic portion of HMG-CoA reductase Fulltext Access 6 Pages 2005
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides Fulltext Access 6 Pages 2005
Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters Fulltext Access 6 Pages 2005