کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10143520 | 1646180 | 2018 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of gene evolution in vertebrate genome reveals novel insights into spine study
ترجمه فارسی عنوان
بررسی تکامل ژن در ژنوم مهره دار، بینش جدیدی را به مطالعه ستون فقرات نشان می دهد
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کلمات کلیدی
FDRNCBIMAP2GAD1glutamate decarboxylase 1Gad2Gene evolution - تکامل ژنMaximum likelihood - حداکثر احتمالSpine - ستون فقراتNational Center for Biotechnology Information - مرکز ملی اطلاعات بیوتکنولوژیVertebrate - مهره دارانfalse discovery rate - میزان کشف کاذبmicrotubule-associated protein 2 - پروتئین مرتبط با میکروتوبول 2Comparative genomics - ژنومیک تطبیقی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
Vertebrate genomes have been considered to have undergone a complicated evolution during their early period and to have generated a large number of genetic templates with novel functions, such as an extended spinal cord and a dorsal central nervous system. However, consistent gene evolution in vertebrate genomes has not been fully elucidated. In this study, we have systematically investigated the gene evolution in vertebrates utilizing a series of comparative genomics tools. We determined that three critical genes were consistently lost in vertebrate genomes, and 14 genes initially emerged in vertebrate formation. Furthermore, another 29 genes were identified with consistent amino acid variation between the vertebrates and invertebrates. A function analysis of five genes (TEP3, ABLIM2, ABLIM3, GAD1 and GAD2) was performed, and their evolution mechanisms in vertebrate genomes further investigated. These findings provide novel insights for studying the vertebrate evolution and spine development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 679, 30 December 2018, Pages 360-368
Journal: Gene - Volume 679, 30 December 2018, Pages 360-368
نویسندگان
Zhiyuan Yang, Fuyan Hu,