Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification

Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 158, 5 October 2018, Pages 270-285

Sarah S. Darwish, Mohammad Abdel-Halim, Ahmed K. ElHady, Mohamed Salah, Ashraf H. Abadi, Walter Becker, Matthias Engel,