The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology

► The new CHO-K1 genome sequence has facilitated advanced systems biology analyses. ► Transcriptomics and proteomics advances provide molecular readouts of CHO physiology. ► 'Omics data sets are also being used to facilitate CHO cell and metabolic engineering. ► 'Omics data are integrated into mathematical models to describe CHO phenotypes. ► Systems biology enhances and accelerates improvements in CHO bioprocessing capacity.