Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis

- Meta-omics permits the study of the biosynthetic gene clusters of uncultivable microbes.
- Unculturable microbe genomes can be sequenced via libraries, directly, or by single cell methods.
- Natural product-specific bioinformatic tools assist metagenomic sequencing data analysis.
- OASIS, PrISM, and derivatives help pave the way for metaproteomic methodologies.
- New techniques link metabolomics to natural products research.