Membrane-associated nanomotors for macromolecular transport

► A novel Protein Homology Network of DNA/protein translocases and related P-loop ATPases. ► Evolution of F-type ATPases and membrane-associated DNA/protein transporters. ► Structural comparison of the motor domain of dsDNA, ssDNA and protein translocases. ► Potential applications in drug/gene delivery, DNA sequencing and bio-nanosensing.