Minicells: Versatile vectors for targeted drug or si/shRNA cancer therapy

► Targeted drug or siRNA delivery in cancer remains a serious hurdle. ► Minicells provide a versatile solution for targeted drug or siRNA delivery. ► Minicell-based delivery packages nanoscale levels of drugs or siRNAs. ► In vivo xenografts in mice show dramatic enhancement of therapeutic index. ► Monkey toxicology trials show repeat dosing without toxicity or immunogenicity.