کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10232302 42498 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Strain improvement by metabolic engineering: lysine production as a case study for systems biology
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Strain improvement by metabolic engineering: lysine production as a case study for systems biology
چکیده انگلیسی
A central goal of systems biology is the elucidation of cell function and physiology through the integrated use of broad based genomic and physiological data. Such systemic approaches have been employed extensively in the past, as they are a central element of metabolic flux analysis, the distribution of kinetic control in pathways, and the key differentiating characteristic of metabolic engineering. In one case study, these tools have been applied to the improvement of lysine-producing strains of Corynebacterium glutamicum. The systematic study of the physiology of this organism allowed the identification of specific metabolic targets and subsequently led to significant improvements in product yield and productivity. This case study can serve as a guide for the development of systems biology tools for the utilization of large volumes of cell- and genome-wide transcriptional and physiological data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Biotechnology - Volume 16, Issue 3, June 2005, Pages 361-366
نویسندگان
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