کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10232790 42537 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Skin biopsies for the measurement of clinical pharmacodynamic biomarkers
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Skin biopsies for the measurement of clinical pharmacodynamic biomarkers
چکیده انگلیسی
The integration of biomarkers reporting on drug pharmacodynamics or on a disease state is becoming necessary in the cost-effective design of clinical trials. Transcriptional changes in skin measured using whole-genome arrays have been useful in assessing the disease state in dermatology. Not only are skin biopsies well-tolerated and easy to obtain, but they sample a system in which many complex signaling and developmental networks are active and in which a wide variety of drug targets may be expected to play a role, either directly or indirectly. Recent advances have led to the use of transcriptional profiling of skin for making pharmacodynamic measurements in clinical trials, even for non-dermatological conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Biotechnology - Volume 16, Issue 6, December 2005, Pages 687-690
نویسندگان
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