Direct approaches to exploit many-core architecture in bioinformatics

► Computing power of the Tile64 many-core microprocessor can be exploited for NGS bioinformatics tasks. ► Tile64 many-core CPU architecture works as a cluster of pico-computers, as with the MC64-NW/SW algorithm. ► MC64-ClustalW shows an important performance improvement with a minor development effort. ► MC64-ABySS reveals that a MPI-like efficient API for Tile64 is essential to port successfully most of the existing parallel code. ► Wide-spreading of many-core CPU technologies could lead to a new paradigm in programming methodologies in the next years.