کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10344638 697950 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
The use of a modified Fedorov exchange algorithm to optimise sampling times for population pharmacokinetic experiments
چکیده انگلیسی
We propose a new algorithm for optimising sampling times for population pharmacokinetic experiments using D-optimality. The algorithm was used in conjunction with the population Fisher information matrix as implemented in MATLAB (PFIM 1.1 and 1.2) to evaluate population pharmacokinetic designs. The new algorithm based on the classical Fedorov exchange algorithm optimises the determinant of the population Fisher information matrix. The performance of the new algorithm has been compared with other existing algorithms including simplex, simulated annealing and adaptive random search. The new algorithm performed better especially when dealing with complex designs at the expense of longer computing times.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 80, Issue 2, November 2005, Pages 115-125
نویسندگان
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