Design of a framework for modeling, integration and simulation of physiological models

► We developed an information technology framework, Phy-SIM, with related analytical and computational tools that facilitates development, integration and simulation of physiological models. ► We proposed mechanisms of modularity that provided the separation of functional and structural aspects of multiscale physiological models, which is a novel contribution to the physiological model development domain. ► We also introduce the concept of information flow, that enables the representation of functional modularity. ► Phy-SIM will provide a modular framework with which more collaborative and integrative studies will be possible.