کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10345535 | 698337 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی کامپیوتر
علوم کامپیوتر (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake Structural identifiability analyses of candidate models for in vitro Pitavastatin hepatic uptake](/preview/png/10345535.png)
چکیده انگلیسی
In this paper a review of the application of four different techniques (a version of the similarity transformation approach for autonomous uncontrolled systems, a non-differential input/output observable normal form approach, the characteristic set differential algebra and a recent algebraic input/output relationship approach) to determine the structural identifiability of certain in vitro nonlinear pharmacokinetic models is provided. The Organic Anion Transporting Polypeptide (OATP) substrate, Pitavastatin, is used as a probe on freshly isolated animal and human hepatocytes. Candidate pharmacokinetic non-linear compartmental models have been derived to characterise the uptake process of Pitavastatin. As a prerequisite to parameter estimation, structural identifiability analyses are performed to establish that all unknown parameters can be identified from the experimental observations available.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Methods and Programs in Biomedicine - Volume 114, Issue 3, May 2014, Pages e60-e69
Journal: Computer Methods and Programs in Biomedicine - Volume 114, Issue 3, May 2014, Pages e60-e69
نویسندگان
Thomas R.B. Grandjean, Michael J. Chappell, James W.T. Yates, Neil D. Evans,